为什么是孟德尔分离现象？

Why Mendelian segregation?

作者信息

Ubeda F

机构信息

St John's College and Oxford Centre for Gene Function, Oxford University, Oxford OX13JP, UK.

出版信息

Biochem Soc Trans. 2006 Aug;34(Pt 4):566-8. doi: 10.1042/BST0340566.

DOI:10.1042/BST0340566

PMID:16856862

Abstract

The discovery of alleles that are able to distort segregation during meiosis in their favour raises the question of why Mendelian segregation is the rule and segregation distortion the exception. Previous research on this topic was limited by an unrealistic assumption: equal segregation in the two sexes. Ubeda and Haig [(2005) Genetics 170, 1345-1357] provide a new model allowing sex-specific segregation distortion. This model shows that natural selection favours departure from Mendelian expectations. The evolutionary instability of Mendelian segregation under more realistic assumptions requires a new paradigm that explains its ubiquity.

摘要

能够在减数分裂过程中偏向自身而扭曲分离的等位基因的发现，引发了一个问题：为什么孟德尔分离是常规，而分离扭曲却是例外。此前关于这个主题的研究受到一个不切实际的假设的限制：两性中的分离相等。乌韦达和黑格[（2005年）《遗传学》170卷，第1345 - 1357页]提出了一个允许性别特异性分离扭曲的新模型。该模型表明，自然选择有利于偏离孟德尔预期。在更现实的假设下孟德尔分离的进化不稳定性需要一个新的范式来解释其普遍性。