与近四倍体核型及复杂基因异常相关的富于T细胞/组织细胞的大B细胞淋巴瘤
T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities.
作者信息
de Leval Laurence, Harris Nancy Lee, Lampertz Serge, Herens Christian
机构信息
Department of Pathology, CHU Sart-Tilman, Liege, Belgium.
出版信息
APMIS. 2006 Jun;114(6):474-8. doi: 10.1111/j.1600-0463.2006.apm_458.x.
Abstract
Cytogenetic data for T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) are scarcely available. We report here a case of THRLBCL with a near-tetraploid karyotype and complex chromosomal aberrations, without rearrangement of BCL2 or BCL6, and characterized pathologically by a variegated morphologic appearance with areas resembling nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL).
摘要
关于富于T细胞/组织细胞的大B细胞淋巴瘤（THRLBCL）的细胞遗传学数据非常有限。我们在此报告一例THRLBCL，其核型接近四倍体且伴有复杂的染色体畸变，无BCL2或BCL6重排，病理特征为形态多样，有类似结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）的区域。
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