Gheorghe Gabriela, Rangarajan Hemalatha G, Camitta Bruce, Segura Annette, Kroft Steven, Southern James F
Department of Pathology and Laboratory Medicine, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI
Pediatric Hematology/Oncology/Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, OH.
Ann Clin Lab Sci. 2015 Winter;45(1):73-8.
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) under-recognized in the pediatric population. A meticulous workup is necessary to avoid a misdiagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or classical Hodgkin lymphoma (HL). A strong degree of suspicion and an emphasis on immunohistochemical staining are required to reach the diagnosis. Few children with advanced stage disease have been described to date. We report two pediatric patients with high stage THRLBCL and highlight their clinical and pathological features.
富于T细胞/组织细胞的大B细胞淋巴瘤（THRLBCL）是弥漫性大B细胞淋巴瘤（DLBCL）的一种独特亚型，在儿科人群中未得到充分认识。进行细致的检查对于避免误诊为结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）或经典型霍奇金淋巴瘤（HL）很有必要。需要高度怀疑并着重进行免疫组化染色才能做出诊断。迄今为止，很少有晚期疾病患儿的相关报道。我们报告了两名高分期THRLBCL的儿科患者，并突出了他们的临床和病理特征。
