Bühren Jens, Kohnen Thomas
Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
J Cataract Refract Surg. 2006 Jul;32(7):1166-74. doi: 10.1016/j.jcrs.2006.01.098.
To identify factors that affect the change in lower- and higher-order wavefront aberrations after myopic wavefront-guided laser in situ keratomileusis (wg-LASIK).
Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
Sixty myopic eyes of 32 patients were treated with wg-LASIK (Zyoptix version 3.1, Bausch & Lomb) and had an uneventful follow-up of 12 months. Wavefront errors were measured preoperatively and 12 months after LASIK and were computed for pupil diameters (PDs) of 3.5 mm and 6.0 mm. Multiple stepwise regression analysis was performed to assess the influence of patient age, spherical equivalent (SE), sphere, cylinder, optical zone (OZ) diameter, and the preoperative individual Zernike coefficients on lower- and higher-order aberration (HOA) change.
The mean preoperative SE was -5.59 diopters (D) +/- 2.20 (SD) (range -1.00 to -9.50 D); the mean OZ diameter was 6.70 +/- 0.68 mm (range 5.6 to 8.1 mm). Reduction in almost all Zernike coefficients was influenced significantly by the preoperative amount of the individual coefficient. The effect varied among the coefficients and was lower with the 6.0 mm PD. With the 3.5 mm PD, age, SE, sphere, cylinder, and OZ diameter did not have a significant effect on individual Zernike coefficients. With the 6.0 mm PD, SE and OZ diameter had a significant effect on the induction of Z4(0); the OZ diameter also had an effect on the induction of coma root mean square.
Three groups of factors influenced the change in HOAs: The negative correlation with the magnitude of preoperative HOA values reflected the effect of the wavefront-guided algorithm. The SE and OZ diameter affected the inadvertent induction of spherical aberrations. Randomly acting effects such as decentration or flap creation, which were not included in the model, affected the induction of HOAs, particularly coma-like terms.
确定影响近视波前引导准分子原位角膜磨镶术（wg-LASIK）后低阶和高阶波前像差变化的因素。
德国美因河畔法兰克福约翰·沃尔夫冈·歌德大学眼科。
32例患者的60只近视眼接受了wg-LASIK治疗（Zyoptix 3.1版，博士伦公司），并进行了为期12个月的平稳随访。术前及LASIK术后12个月测量波前像差，并计算3.5mm和6.0mm瞳孔直径（PD）时的波前像差。进行多元逐步回归分析，以评估患者年龄、等效球镜度（SE）、球镜、柱镜、光学区（OZ）直径以及术前个体泽尼克系数对低阶和高阶像差（HOA）变化的影响。
术前平均SE为-5.59屈光度（D）±2.20（标准差）（范围-1.00至-9.50D）；平均OZ直径为6.70±0.68mm（范围5.6至8.1mm）。几乎所有泽尼克系数的降低都受到术前个体系数大小的显著影响。不同系数的影响各不相同，6.0mm PD时影响较小。对于3.5mm PD，年龄、SE、球镜、柱镜和OZ直径对个体泽尼克系数无显著影响。对于6.0mm PD，SE和OZ直径对Z4(0)的诱导有显著影响；OZ直径对彗差均方根的诱导也有影响。
三组因素影响HOA的变化：与术前HOA值大小的负相关反映了波前引导算法的作用。SE和OZ直径影响了球差的意外诱导。模型中未包括的诸如偏心或瓣制作等随机作用影响了HOA的诱导，尤其是类彗差项。
