Medeiros Décio, Silva Almerinda Rego, Rizzo José Angelo, Motta Maria Eugênia, Oliveira Francisca Hosana Bezerra de, Sarinho Emanuel Sávio Cavalcanti
Departamento Materno-Infantil, Universidade Federal de Pernambuco (UFPE), CEP 52060-000 Recife, PE, Brazil.
J Pediatr (Rio J). 2006 Jul-Aug;82(4):255-9. doi: 10.2223/JPED.1503. Epub 2006 Jul 19.
Eosinophilia and increased serum IgE levels are indicators of atopy; however, other factors can also play a key role, such as intestinal parasitic infections. This study assesses the relationship between total serum IgE, eosinophil count, and anti-Ascaris IgE in individuals with asthma and/or allergic rhinitis.
A cross-sectional study was carried out in adolescents with asthma and/or allergic rhinitis. The patients had their total serum IgE, anti-Ascaris IgE and eosinophil count measured.
A total of 101 patients aged 12 to 21 years were assessed. Median IgE level was 660 IU/mL (P(25-75) 243.5-1500), and the eosinophil count corresponded to 510 cells/mm(3) (P(25-75) 284-811). Anti-Ascaris IgE was positive in 73% (74/101) of the individuals, but parasitological stool examination yielded positive results in only 33.7% (34/101). The correlation coefficients were the following: 0.34 (p = 0.001) between total IgE level and eosinophil count, 0.52 (p < 0.001) between total IgE level and anti-Ascaris IgE, and 0.26 (p = 0.01) between eosinophil count and anti-Ascaris IgE. The final multiple linear regression model pointed out that anti-Ascaris IgE contributed to a total serum IgE level with a coefficient of determination (adjusted R(2)) of 0.25 (F = 12.35; p < 0.001). This effect occurred regardless of eosinophil count and of the presence of intestinal helminthic infection.
In patients with respiratory allergy and increased total serum IgE levels living in areas where there is a high risk for helminthic infections, the quantification of anti-Ascaris IgE can be more useful and more insightful than the parasitological stool examination.
嗜酸性粒细胞增多和血清IgE水平升高是特应性的指标；然而，其他因素也可能起关键作用，如肠道寄生虫感染。本研究评估哮喘和/或过敏性鼻炎患者血清总IgE、嗜酸性粒细胞计数与抗蛔虫IgE之间的关系。
对患有哮喘和/或过敏性鼻炎的青少年进行横断面研究。测量患者的血清总IgE、抗蛔虫IgE和嗜酸性粒细胞计数。
共评估了101例年龄在12至21岁之间的患者。IgE水平中位数为660 IU/mL（P(25 - 75) 243.5 - 1500），嗜酸性粒细胞计数为510个细胞/mm³（P(25 - 75) 284 - 811）。73%（74/101）的个体抗蛔虫IgE呈阳性，但粪便寄生虫学检查仅33.7%（34/101）呈阳性。相关系数如下：血清总IgE水平与嗜酸性粒细胞计数之间为0.34（p = 0.001），血清总IgE水平与抗蛔虫IgE之间为0.52（p < 0.001），嗜酸性粒细胞计数与抗蛔虫IgE之间为0.26（p = 0.01）。最终的多元线性回归模型指出，抗蛔虫IgE对血清总IgE水平有贡献，决定系数（调整R²）为0.25（F = 12.35；p < 0.001）。无论嗜酸性粒细胞计数和肠道蠕虫感染情况如何，这种影响都存在。
在生活于蠕虫感染高风险地区且血清总IgE水平升高的呼吸道过敏患者中，抗蛔虫IgE的定量检测可能比粪便寄生虫学检查更有用、更具洞察力。
