印度尼西亚一个城市社区中有和没有哮喘、喘息或特应性病史的儿童的血清总IgE和嗜酸性粒细胞计数。呼吸疾病工作组。

Total serum IgE and eosinophil count in children with and without a history of asthma, wheezing, or atopy in an urban community in Indonesia. The Respiratory Disease Working Group.

作者信息

Kartasamita C B, Rosmayudi O, Demedts M

机构信息

Medical Faculty, Padjadjaran University, Bandung, Indonesia.

出版信息

J Allergy Clin Immunol. 1994 Dec;94(6 Pt 1):981-8. doi: 10.1016/0091-6749(94)90116-3.

DOI:10.1016/0091-6749(94)90116-3

PMID:7798546

Abstract

AIM

The objectives of the study were to assess total serum IgE and eosinophil count in a random sample of 20% of the children between 12 and 54 months old in a suburban community of Bandung, Indonesia, and to investigate a possible relationship between these values and atopy, asthma or wheezing and parasite infestation.

METHODS

Two hundred sixty-nine children were examined at the Integrated Primary Health Care Unit, and the parents or guardians were interviewed with the use of a standardized questionnaire.

RESULTS

The overall median value of IgE was 436 IU/ml (range, 18 to 9707 IU/ml); almost 94% of the children showed an IgE value of more than 100 IU/ml, and 29% showed a value of more than 1000 IU/ml. The median value for eosinophils was 580/mm3 (range, 70 to 5090/mm3); only 31% of the children had less than 400 eosinophils/mm3. IgE levels and eosinophilia were not related to age but showed a significant, although not high, correlation with each other (p < 0.05). In about 36% of the children parasites were demonstrated in a single stool sample; in those subjects eosinophilia and IgE values tended to be greater, but the difference was not significant. About 7% of the children had asthma, and in those subjects the eosinophil counts and IgE levels were much more increased (p < 0.001 and p approximately 0.01, respectively). No difference was found in IgE or eosinophil count in relation to other forms of atopy in the child (milk-induced dermatitis, urticaria, eczema, rhinitis) or in relation to a history of asthma or atopy in other family members. Yet, the occurrence of asthma in the child was significantly related to a history of asthma in other family members.

CONCLUSIONS

IgE values and eosinophilia are markedly increased in these children under 5 years of age in Bandung, Indonesia, and the highest values are found in the 7% with asthma.

摘要

目的

本研究的目的是评估印度尼西亚万隆郊区社区20%的12至54个月大儿童的血清总IgE和嗜酸性粒细胞计数，并调查这些数值与特应性、哮喘或喘息以及寄生虫感染之间可能存在的关系。

方法

在综合初级卫生保健单位对269名儿童进行了检查，并使用标准化问卷对其父母或监护人进行了访谈。

结果

IgE的总体中位数为436 IU/ml（范围为18至9707 IU/ml）；近94%的儿童IgE值超过100 IU/ml，29%的儿童IgE值超过1000 IU/ml。嗜酸性粒细胞的中位数为580/mm³（范围为70至5090/mm³）；只有31%的儿童嗜酸性粒细胞低于400/mm³。IgE水平和嗜酸性粒细胞增多与年龄无关，但彼此之间存在显著相关性（虽不高）（p<0.05）。约36%的儿童在单次粪便样本中检测出寄生虫；在这些受试者中，嗜酸性粒细胞增多和IgE值往往更高，但差异不显著。约7%的儿童患有哮喘，在这些受试者中，嗜酸性粒细胞计数和IgE水平显著升高（分别为p<0.001和p约为0.01）。在儿童的其他特应性形式（牛奶诱发的皮炎、荨麻疹、湿疹、鼻炎）方面，或在其他家庭成员有哮喘或特应性病史方面，未发现IgE或嗜酸性粒细胞计数有差异。然而，儿童哮喘的发生与其他家庭成员的哮喘病史显著相关。