终末期肾病中的痴呆与抑郁：血液透析与持续性非卧床腹膜透析的比较

Dementia and depression in end stage renal disease: comparison between hemodialysis and continuous ambulatory peritoneal dialysis.

作者信息

Sithinamsuwan Pasiri, Niyasom Suchada, Nidhinandana Samart, Supasyndh Ouppatham

机构信息

Division of Neurology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.

出版信息

J Med Assoc Thai. 2005 Nov;88 Suppl 3:S141-7.

PMID:16858952

Abstract

OBJECTIVES

To determine the prevalence, risk factors of dementia and depression in end stage renal disease (ESRD) who were treated with hemodialysis (HD) compared with those who had continuous ambulatory peritoneal dialysis (CAPD).

MATERIAL AND METHOD

A cross-sectional study was conducted on 90 ESRD patients (60 HD and 30 CAPD groups). The authors reviewed the demographic data, investigation results. Thai Mental State Examination, DSM IV criteria and Thai Depression Inventory were interviewed to determine dementia and depression respectively.

RESULTS

Both prevalence of dementia and depression in ESRD on continuous dialysis were 6.7%. In the HD group had 8.3% prevalence of dementia and 6.7% of depression, whereas there was 3.3% of dementia and 6.7% of depression in the CAPD group. The severity of depression in the present study was mild to moderate (6.7%) and no major depression was seen. The significant risk factors for dementia were age > or = 60 years (p=0.003), Education < 10 years (p=0.037) and female sex (p=0.036). The significant risk factor for depression was female sex (p=0.036). There was no significance different on prevalence of dementia and depression comparison between the HD and CAPD group.

CONCLUSION

Prevalence of dementia and depression in the overall dialysis in ESRD was 6.7% (with 8.3%, 6.7% among the HD group and 3.3%, 6.7% among CAPD group). There was no significant difference on prevalence of dementia and depression comparison between the HD and CAPD group.

摘要

目的

确定接受血液透析（HD）治疗的终末期肾病（ESRD）患者与接受持续性非卧床腹膜透析（CAPD）治疗的患者相比，痴呆和抑郁的患病率及危险因素。

材料与方法

对90例ESRD患者（60例HD组和30例CAPD组）进行了一项横断面研究。作者回顾了人口统计学数据、检查结果。分别采用泰国精神状态检查、DSM-IV标准和泰国抑郁量表对患者进行访谈以确定痴呆和抑郁情况。

结果

持续透析的ESRD患者中痴呆和抑郁的患病率均为6.7%。HD组痴呆患病率为8.3%，抑郁患病率为6.7%；而CAPD组痴呆患病率为3.3%，抑郁患病率为6.7%。本研究中抑郁的严重程度为轻度至中度（6.7%），未见重度抑郁。痴呆的显著危险因素为年龄≥60岁（p = 0.003）、教育年限<10年（p = 0.037）和女性（p = 0.036）。抑郁的显著危险因素为女性（p = 0.036）。HD组和CAPD组在痴呆和抑郁患病率比较上无显著差异。