Kuljanac Ilko
Department of Dermatology and Venereology, Karlovac General Hospital, A Stampara 3, HR-47000 Karlovac, Croatia.
Acta Dermatovenerol Croat. 2006;14(2):86-9.
The role of Dermatophagoides (D.) pteronyssinus in atopic dermatitis (AD) was investigated by use of skin prick test (SPT) and total and specific IgE (RAST) to D. pteronyssinus. The study included 43 patients (17 male and 26 female), mean age 42.3 (range 19-77) years. All study patients met the Hanifin and Rajka criteria. Patients were divided into two groups: "pure" AD (n=27; 12 male and 15 female), mean age 46.3 (range 19-77) years; and AD with respiratory symptoms (AD+RS, n=16; 5 male and 11 female), mean age 38.4 (range 17-75) years. Control group consisted of 15 healthy subjects (7 male and 8 female; mean age 49.0, range 24-64 years), with no personal or family history and signs of atopy. Both patient groups had a higher total serum IgE than control subjects (p<0.05). In the "pure" AD group, SPT was positive in 5/27 (18.5%) and RAST to D. pteronyssinus in 4/27 patients. In the AD+RS group, SPT was positive in 10/16 (62.5%) and RAST to D. pteronyssinus in 8/16 (50%) patients. Concordance between SPT and RAST was observed in both groups; 80% of SPT positive patients were RAST positive. D. pteronyssinus was found to play an important role as a trigger factor in AD patients.
通过对粉尘螨进行皮肤点刺试验（SPT）以及检测粉尘螨的总免疫球蛋白E（IgE）和特异性IgE（RAST），研究了粉尘螨在特应性皮炎（AD）中的作用。该研究纳入了43例患者（17例男性和26例女性），平均年龄42.3岁（范围19 - 77岁）。所有研究患者均符合哈尼芬和拉伊卡标准。患者被分为两组：“单纯”AD组（n = 27；12例男性和15例女性），平均年龄46.3岁（范围19 - 77岁）；以及伴有呼吸道症状的AD组（AD + RS，n = 16；5例男性和11例女性），平均年龄38.4岁（范围17 - 75岁）。对照组由15名健康受试者组成（7例男性和8例女性；平均年龄49.0岁，范围24 - 64岁），无个人或家族特应性病史及体征。两个患者组的血清总IgE均高于对照组（p < 0.05）。在“单纯”AD组中，27例患者中有５例（18.5%）皮肤点刺试验呈阳性，27例患者中有4例（14.8%）粉尘螨RAST呈阳性。在AD + RS组中，16例患者中有10例（62.5%）皮肤点刺试验呈阳性，16例患者中有8例（50%）粉尘螨RAST呈阳性。两组中皮肤点刺试验和RAST之间均存在一致性；80%皮肤点刺试验阳性的患者RAST也呈阳性。研究发现粉尘螨在AD患者中作为触发因素起重要作用。
