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产后早期α-甲基多巴治疗对大鼠行为的影响。

Effects of early post-natal alpha-methyl-dopa treatment on behavior in the rat.

作者信息

Juvancz P, Nowaczyk T

出版信息

Psychopharmacologia. 1975 Apr 30;42(1):95-7. doi: 10.1007/BF00428832.

DOI:10.1007/BF00428832
PMID:168606
Abstract

250 mg/kg of L-alpha-methyl-Dopa (alpha-m-Dopa) or saline were administered to rats for three weeks after birth. Subsequent tests revealed an increased locomotor activity and greater rate of acquisition but no disturbance in shuttle-box conditioning. The whole brain content of norepinephrine, dopamine and serotonin was not affected.

摘要

出生后三周,给大鼠注射250毫克/千克的L-α-甲基多巴(α-m-多巴)或生理盐水。后续测试显示,大鼠的自发活动增加,习得率提高,但穿梭箱条件反射未受干扰。去甲肾上腺素、多巴胺和血清素的全脑含量未受影响。

相似文献

1
Effects of early post-natal alpha-methyl-dopa treatment on behavior in the rat.产后早期α-甲基多巴治疗对大鼠行为的影响。
Psychopharmacologia. 1975 Apr 30;42(1):95-7. doi: 10.1007/BF00428832.
2
The sleep of artificially reared newborn rats, effect of alpha-methyl-DOPA treatment on paradoxical sleep and on adult behaviour.人工饲养新生大鼠的睡眠、α-甲基多巴治疗对异相睡眠及成年行为的影响
Acta Physiol Acad Sci Hung. 1981;57(1):87-98.
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[The development of sleep in newborn rat separated from its mother. Effects of alpha-methyl-dopa (author's transl)].
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引用本文的文献

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Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.新生大鼠使用去甲丙咪嗪或齐美利定治疗会导致大脑单胺能系统以及与酒精相关行为的长期改变。
Psychopharmacology (Berl). 1987;91(4):403-9. doi: 10.1007/BF00216004.

本文引用的文献

1
SINGLE EXTRACTION METHOD FOR THE SIMULTANEOUS FLUOROMETRIC DETERMINATION OF SEROTONIN, DOPAMINE, AND NOREPINEPHRINE IN BRAIN.用于同时荧光测定脑中血清素、多巴胺和去甲肾上腺素的单次提取法
Anal Chem. 1965 May;37:692-6. doi: 10.1021/ac60225a016.
2
Improved technique for the fluorimetric estimation of catecholamines.儿茶酚胺荧光测定的改进技术。
Acta Physiol Scand. 1961 Apr;51:348-55. doi: 10.1111/j.1748-1716.1961.tb02128.x.
3
Neonatal sympathectomy by 6-hydroxydopamine in the rat: no effects on behavior by changes in endogenous brain norepinephrine.
用6-羟基多巴胺对大鼠进行新生儿交感神经切除术:内源性脑去甲肾上腺素的变化对行为无影响。
Life Sci I. 1972 Jul 15;11(14):653-9. doi: 10.1016/0024-3205(72)90035-5.
4
[The development of sleep in newborn rat separated from its mother. Effects of alpha-methyl-dopa (author's transl)].
Psychopharmacologia. 1974 Jul 11;37(3):205-15. doi: 10.1007/BF00421534.
5
[Intracisternal 6-hydroxydopamine and sleep in the rat].[大鼠脑池内注射6-羟基多巴胺与睡眠]
Brain Res. 1973 Jul 16;57(1):85-95. doi: 10.1016/0006-8993(73)90570-2.
6
[Demonstration of paradoxal sleep in utero in guinea pigs].[豚鼠子宫内异相睡眠的证明]
C R Acad Hebd Seances Acad Sci D. 1969 Dec 22;269(25):2578-81.
7
Insomnia following parachlorophenylalanine in the rat.大鼠服用对氯苯丙氨酸后的失眠现象。
Eur J Pharmacol. 1968 Dec;5(1):17-22. doi: 10.1016/0014-2999(68)90151-9.
8
Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine.脑室内注射6-羟基多巴胺对发育中大鼠生长及行为变化的影响:脑多巴胺参与其中的证据
J Pharmacol Exp Ther. 1973 Jun;185(3):609-19.