Eilam D, Clements K V, Szechtman H
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Behav Brain Res. 1991 Nov 26;45(2):117-24. doi: 10.1016/s0166-4328(05)80077-4.
The study examines the effect of selective D1 dopamine stimulation with SKF38393 (1.25-10 mg/kg), on stereotyped locomotion induced by the D2 agonist, quinpirole (0.5 mg/kg). Quinpirole induces repeated travel along a few routes in a limited portion of the environment. Co-administration of low doses of SKF38393 (1.25-2.5 mg/kg) produces the following results: the rate of route perseveration is not affected; the area explored expands to encompass the entire periphery of the open field; and, spatial distribution of locomotion is transformed from routes that cross the center under quinpirole to travel only along the edge. Under higher doses of SKF38393, locomotion ceases. These findings suggest that D1 and D2 stimulation may control the spatial organization of locomotion in oppositional rather than synergistic manner.
该研究考察了用SKF38393（1.25 - 10毫克/千克）选择性刺激D1多巴胺对由D2激动剂喹吡罗（0.5毫克/千克）诱导的刻板运动的影响。喹吡罗会诱导在环境的有限区域内沿着几条路线反复行进。联合给予低剂量的SKF38393（1.25 - 2.5毫克/千克）会产生以下结果：路线 perseveration 的速率不受影响；探索的区域扩大到涵盖开放场地的整个周边；并且，运动的空间分布从喹吡罗作用下穿过中心的路线转变为仅沿着边缘行进。在更高剂量的SKF38393作用下，运动停止。这些发现表明，D1和D2刺激可能以相反而非协同的方式控制运动的空间组织。 （注：“route perseveration”这里可能有误，推测原文可能是“route preference”之类的表述，不然“路线 perseveration”不太能准确理解其确切含义）
