Behavioral interactions between muscimol and compounds selective for the D1 and D2 dopamine receptor subtypes. - Suppr | 超能文献

Behavioral interactions between muscimol and compounds selective for the D1 and D2 dopamine receptor subtypes.

作者信息

Asin K E, Bednarz L M

机构信息

Neuroscience Research Division, Abbott Laboratories, Abbott Park, IL 60064.

出版信息

Neurosci Lett. 1990 Jun 8;113(3):286-91. doi: 10.1016/0304-3940(90)90599-5.

DOI:10.1016/0304-3940(90)90599-5

Abstract

The present study investigated the effects of the GABA agonist muscimol on the behaviors produced by acute injections of selective D1 and D2 agonists and antagonists. Muscimol potentiated the intensity of stereotyped behaviors shown by rats treated with the D2 agonist quinpirole; in contrast, it suppressed the repetitive bouts of grooming shown by rats treated with SKF38393. Muscimol potentiated the catalepsy produced by either a D1 (SCH23390) or D2 (metoclopramide) antagonist, suggesting that the cataleptic behaviors produced by these compounds may contain a common GABAergic mechanism.

摘要

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Behavioral interactions between muscimol and compounds selective for the D1 and D2 dopamine receptor subtypes.

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Dynamic modelling of the binding of substances to the conserved membrane-adjacent heptapeptide of the 15-residue C-terminal cytoplasmic fragment of mammalian dopamine D2 receptors.物质与哺乳动物多巴胺D2受体15个残基的C末端胞质片段中保守的膜相邻七肽结合的动态建模。

Neurochem Res. 1996 Feb;21(2):177-200. doi: 10.1007/BF02529135.

2

Parametric and pharmacological analyses of the enhanced grooming response elicited by the D1 dopamine receptor agonist SKF 38393 in the rat.对D1多巴胺受体激动剂SKF 38393在大鼠中引发的增强梳理反应的参数和药理学分析。

Psychopharmacology (Berl). 1992;109(1-2):41-8. doi: 10.1007/BF02245478.

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