Asin K E, Bednarz L M
Neuroscience Research Division, Abbott Laboratories, Abbott Park, IL 60064.
Neurosci Lett. 1990 Jun 8;113(3):286-91. doi: 10.1016/0304-3940(90)90599-5.
The present study investigated the effects of the GABA agonist muscimol on the behaviors produced by acute injections of selective D1 and D2 agonists and antagonists. Muscimol potentiated the intensity of stereotyped behaviors shown by rats treated with the D2 agonist quinpirole; in contrast, it suppressed the repetitive bouts of grooming shown by rats treated with SKF38393. Muscimol potentiated the catalepsy produced by either a D1 (SCH23390) or D2 (metoclopramide) antagonist, suggesting that the cataleptic behaviors produced by these compounds may contain a common GABAergic mechanism.
本研究调查了γ-氨基丁酸（GABA）激动剂蝇蕈醇对急性注射选择性D1和D2激动剂及拮抗剂所产生行为的影响。蝇蕈醇增强了用D2激动剂喹吡罗处理的大鼠所表现出的刻板行为的强度；相反，它抑制了用SKF38393处理的大鼠所表现出的反复梳理行为。蝇蕈醇增强了由D1拮抗剂（SCH23390）或D2拮抗剂（甲氧氯普胺）所产生的僵住症，这表明这些化合物所产生的僵住行为可能包含一个共同的GABA能机制。
