Utian W H
S Afr Med J. 1975 Mar 19;49(12):433-6.
The role of oestrogens, endogenous and exogenous, in the pathogenesis of osteoporis is briefly reviewed. Aspects of research into effects of oestrogens on plasma calcium and phosphorus metabolism, conducted at Groote Schuur Hospital, are incorporated in the discussion. The current role of oestrogen therapy in the prevention of osteoporosis is presented. Evidence suggests that different oestrogenic substances produce different metabolic effects. On this basis a new test for assessment of oestrogenic potency is proposed. It is concluded that appropriate or specific oestrogens are of value in the prevention of osteoporosis, but play little or no role once the process is fully developed. A positive preventive measure recommended is conservatism with regard to ovaries during gynaecological operation on young women.
本文简要回顾了内源性和外源性雌激素在骨质疏松症发病机制中的作用。讨论中纳入了在格罗特舒尔医院进行的关于雌激素对血浆钙和磷代谢影响的研究方面。介绍了雌激素疗法在预防骨质疏松症中的当前作用。有证据表明，不同的雌激素物质会产生不同的代谢效应。在此基础上，提出了一种评估雌激素效力的新测试。结论是，适当的或特定的雌激素在预防骨质疏松症方面具有价值，但一旦该过程完全发展，其作用很小或没有作用。推荐的一项积极预防措施是在年轻女性进行妇科手术时对卵巢采取保守态度。
