Mehta P V
Postgrad Med J. 1978 Jun;54(632):386-90. doi: 10.1136/pgmj.54.632.386.
In the pre-menopausal years, the ovarian secretion waxes and wanes until its cessation. In this study of women in the pre-menopausal period neither did the menstrual pattern prove to be a reliable criterion by which to judge the extent of oestrogen effect or deficiency nor was there correlation between serial colpocytology and endometrial histology, Hyperplasia of the endometrium was seen with different degrees of oestrogen status and in the menopause. Maximum cases of hyperplasia were seen in the irregularly menstruating group of women. It is therefore emphasized that before beginning oestrogen therapy, both colpocytology and endometrial histology should concur to establish oestrogen deficiency. A close watch should be kept on cases showing an endometrial hyperplasia.
在绝经前的岁月里，卵巢分泌呈周期性变化，直至停止。在这项针对绝经前期女性的研究中，月经模式既未被证明是判断雌激素作用程度或缺乏程度的可靠标准，连续的阴道细胞学检查与子宫内膜组织学之间也不存在相关性。在不同雌激素状态下以及绝经时均可见子宫内膜增生。子宫内膜增生的最大病例数见于月经不规律的女性群体。因此，强调在开始雌激素治疗前，阴道细胞学检查和子宫内膜组织学检查应一致，以确定雌激素缺乏。对于显示子宫内膜增生的病例应密切观察。
