肥胖是转化型偏头痛的一个风险因素，但不是慢性紧张型头痛的风险因素。

Obesity is a risk factor for transformed migraine but not chronic tension-type headache.

作者信息

Bigal Marcelo E, Lipton Richard B

机构信息

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Neurology. 2006 Jul 25;67(2):252-7. doi: 10.1212/01.wnl.0000225052.35019.f9.

DOI:10.1212/01.wnl.0000225052.35019.f9

PMID:16864817

Abstract

OBJECTIVE

To assess the influence of the body mass index (BMI) on the prevalence and severity of chronic daily headache (CDH) and its most frequent subtypes, transformed migraine (TM) and chronic tension-type headache (CTTH).

METHODS

The authors gathered information on headache, medical features, height, and weight using a computer-assisted telephone interview. Participants were divided into five categories, based on BMI: underweight (<18.5), normal weight (18.5 to 24.9), overweight (25 to 29.9), obese (30 to 34.9), and morbidly obese (>35). The prevalence and severity of CDH, TM, and CTTH were assessed. Multivariate analyses modeling these diagnoses as a function of BMI were conducted.

RESULTS

Among 30,215 participants, the prevalence of CDH was 4.1%; 1.3% had TM and 2.8% CTTH. In contrast with the normal weight group (3.9%), the prevalence of CDH was higher in obese (5.0% [odds ratio (OR) = 1.3, 95% CI = 1.1-1.6]) and morbidly obese (6.8% [OR = 1.8, 95% CI = 1.4 to 2.2]). BMI had a strong influence on the prevalence of TM, which ranged from 0.9% of the normal weighted to 1.2% of the overweight (OR = 1.4 [1.1 to 1.8]), 1.6% of the obese (OR = 1.7 [1.2 to 2.43]), and 2.5% of the morbidly obese (OR = 2.2 [1.5 to 3.2]). The effects of the BMI on the prevalence of CTTH were just significant in the morbidly obese group. Adjusted analyses showed that obesity was associated with CDH and TM but not CTTH.

CONCLUSIONS

Chronic daily headache and obesity are associated. Obesity is a stronger risk factor for transformed migraine than for chronic tension-type headache.

摘要

目的

评估体重指数（BMI）对慢性每日头痛（CDH）及其最常见亚型——转化型偏头痛（TM）和慢性紧张型头痛（CTTH）的患病率及严重程度的影响。

方法

作者通过计算机辅助电话访谈收集了有关头痛、医学特征、身高和体重的信息。参与者根据BMI分为五类：体重过轻（<18.5）、正常体重（18.5至24.9）、超重（25至29.9）、肥胖（30至34.9）和病态肥胖（>35）。评估了CDH、TM和CTTH的患病率及严重程度。进行了多变量分析，将这些诊断作为BMI的函数进行建模。

结果

在30215名参与者中，CDH的患病率为4.1%；1.3%患有TM，2.8%患有CTTH。与正常体重组（3.9%）相比，肥胖组（5.0%[优势比（OR）=1.3，95%置信区间（CI）=1.1 - 1.6]）和病态肥胖组（6.8%[OR =1.8，95%CI =1.4至2.2]）中CDH的患病率更高。BMI对TM的患病率有很大影响，TM的患病率在正常体重者中为0.9%，超重者中为1.2%（OR =1.4[1.1至1.8]），肥胖者中为1.6%（OR =1.7[1.2至2.43]），病态肥胖者中为2.5%（OR =2.2[1.5至3.2]）。BMI对CTTH患病率的影响仅在病态肥胖组中显著。校正分析表明，肥胖与CDH和TM相关，但与CTTH无关。