Nastiti K, Benton D, Brain P F, Haug M
Biological Sciences, University College of Swansea, UK.
Neurosci Biobehav Rev. 1991 Winter;15(4):483-7. doi: 10.1016/s0149-7634(05)80136-8.
The influence of a range of drugs acting at various 5-HT receptor sites on the ultrasonic calling of mouse pups was assessed. Calling was decreased by the novel anxiolytics buspirone, ipsapirone and gepirone, and by TFMPP, spiperone, ritanserin and GR 38032F. In contrast, 8-OH-DPAT, DOI and quipazine increased the rate of calling. These effects on ultrasonic calling were independent of sedative or thermoregulatory actions of these drugs. Present data provide further support for the view that ultrasonic calling can be used to assess novel compounds for possible anxiolytic or anxiogenic properties.
评估了一系列作用于不同5-羟色胺（5-HT）受体位点的药物对幼鼠超声波鸣叫的影响。新型抗焦虑药丁螺环酮、伊沙匹隆和吉哌隆，以及三氟甲基苯哌嗪、螺哌隆、利坦色林和GR 38032F可使鸣叫减少。相比之下，8-羟基二苯丙胺、DOI和喹哌嗪可提高鸣叫频率。这些药物对超声波鸣叫的影响与它们的镇静或体温调节作用无关。目前的数据进一步支持了这样一种观点，即超声波鸣叫可用于评估新型化合物是否具有潜在的抗焦虑或致焦虑特性。
