Benton D, Nastiti K
Department of Psychology, University College, Swansea, Wales, UK.
Psychopharmacology (Berl). 1988;95(1):99-102. doi: 10.1007/BF00212775.
The influence of a range of commonly used psychotherapeutic drugs on the ultrasonic calling of mouse pups was assessed. The major tranquilizers chlorpromazine and haloperidol were without effect. Whereas tranylcypromine and imipramine were also inactive, amitriptyline suppressed the rate of calling. Some anxiolytic compounds such as meprobamate and amobarbital were without influence, although others such as diazepam, chlordiazepoxide and ipsapirone decreased the number of calls. The influence of these drugs on body temperature was measured, as it is known to markedly influence the rate of ultrasonic calling. Although six out of ten drugs decreased body temperature, there was no evidence that this was related to the rate of ultrasonic calling. The possibility that the recording of ultrasonic calls could be used to screen for psychotropic activity is discussed.
评估了一系列常用心理治疗药物对幼鼠超声发声的影响。主要镇静剂氯丙嗪和氟哌啶醇没有效果。反苯环丙胺和丙咪嗪也没有活性，而阿米替林抑制了发声频率。一些抗焦虑化合物如眠尔通和异戊巴比妥没有影响，尽管其他一些如地西泮、氯氮卓和伊沙匹隆减少了叫声次数。测量了这些药物对体温的影响，因为已知体温会显著影响超声发声频率。尽管十分之六的药物降低了体温，但没有证据表明这与超声发声频率有关。讨论了利用超声叫声记录来筛选精神活性的可能性。
