Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, China.
Ir J Med Sci. 2010 Sep;179(3):345-9. doi: 10.1007/s11845-010-0494-2. Epub 2010 Jun 2.
To evaluate the role of fasting plasma ghrelin levels [ln(ghrelin)] and polymorphisms of ghrelin gene in Chinese obese children.
Genotyping for ghrelin polymorphism was performed in 230 obese and 100 normal weight children. Among them, plasma ghrelin levels were measured in 91 obese and 23 health subjects.
(1) Bivariate correlation analysis showed the ln(ghrelin) was inversely correlated with abnormality of glucose metabolism (r = -0.240, P = 0.023). Stepwise multiple regression analysis showed that abnormality of glucose metabolism was an independent determinant of plasma ghrelin levels (P = 0.023). (2) There was no difference in frequency of Leu72Met polymorphisms between obese and control groups (36.09 vs. 41.00%).
Ghrelin is associated with obesity in childhood, especially associated with the glucose homeostasis. Lower ghrelin levels might be a result of obesity, but not a cause of obesity. The Leu72Met polymorphism of ghrelin gene is not associated with obesity and metabolic syndrome in Chinese children.
评估禁食血浆生长激素释放肽水平[ln（ghrelin）]和生长激素释放肽基因多态性在中国肥胖儿童中的作用。
对 230 名肥胖儿童和 100 名正常体重儿童进行生长激素释放肽基因多态性基因分型。其中，91 名肥胖儿童和 23 名健康受试者测量了血浆生长激素释放肽水平。
（1）双变量相关分析显示，ln（ghrelin）与糖代谢异常呈负相关（r=-0.240，P=0.023）。逐步多元回归分析显示，糖代谢异常是血浆生长激素释放肽水平的独立决定因素（P=0.023）。（2）肥胖组和对照组 Leu72Met 多态性的频率无差异（36.09%比 41.00%）。
ghrelin 与儿童肥胖有关，特别是与葡萄糖稳态有关。较低的 ghrelin 水平可能是肥胖的结果，而不是肥胖的原因。ghrelin 基因的 Leu72Met 多态性与中国儿童肥胖和代谢综合征无关。
