Schulz K-H, Gold S
Universitätsklinikum Eppendorf, Transplantationszentrum und Institut für Medizinische Psychologie, Martinistrasse 52, Gebäude S35, 20246 Hamburg, BRD.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2006 Aug;49(8):759-72. doi: 10.1007/s00103-006-0006-8.
Interdisciplinary psychoneuroimmunological (PNI) research increasingly demonstrates clinically relevant interrelations between psychological stressors and the onset or progression of chronic diseases. Disturbances of the bi-directional interaction between the nervous system, the immune system and the endocrine system have been hypothesized to be implicated in several diseases. Here, we review evidence from psychoneuroimmunology within the theoretical framework of allostatic load to conceptualize some of these associations. Interdisciplinary PNI research investigating the importance of psychological stress for the higher incidence of infections, decreased responses to vaccinations and delayed wound healing is reviewed. Furthermore, the literature supporting similar associations with regard to progression of oncological diseases and autoimmune disorders is reviewed with a focus on breast cancer and multiple sclerosis. The accumulating evidence regarding the importance of neuroendocrine-immune interaction in these diseases may thus lead to novel insights into pathogenetic mechanisms and could contribute to the development of novel preventive and therapeutic strategies.
跨学科心理神经免疫学（PNI）研究越来越多地证明了心理压力源与慢性疾病的发生或进展之间存在临床相关的相互关系。神经系统、免疫系统和内分泌系统之间双向相互作用的紊乱被认为与多种疾病有关。在此，我们在应激负荷的理论框架内回顾心理神经免疫学的证据，以将其中一些关联概念化。我们回顾了跨学科PNI研究，该研究调查了心理压力对感染发生率较高、疫苗接种反应降低和伤口愈合延迟的重要性。此外，还回顾了支持在肿瘤疾病进展和自身免疫性疾病方面存在类似关联的文献，重点是乳腺癌和多发性硬化症。因此，关于神经内分泌 - 免疫相互作用在这些疾病中的重要性的证据不断积累，可能会带来对发病机制的新见解，并有助于开发新的预防和治疗策略。
