Cecchi Roberto, Rapicano Valentina
Department of Dermatology, Spedali Riuniti, Pistoia, Italy.
Australas J Dermatol. 2006 Aug;47(3):192-4. doi: 10.1111/j.1440-0960.2006.00271.x.
We present a 72-year-old woman who presented with a slowly enlarging, asymptomatic, cystic nodule on the right eyebrow, and a 66-year-old woman who had a reddish, nodular lesion on the left lower eyelid. Incisional biopsy from the two neoplasms showed dermal epithelial cell islands embedded in mucin pools. Tumour cells stained positive for cytokeratin 7, oestrogen and progesterone receptors, and negative for vimentin and S-100 protein. These findings were consistent with a diagnosis of mucinous carcinoma. Extensive work-ups excluded cutaneous metastases from primary visceral mucinous carcinomas. To ensure complete tumour removal, both patients underwent Mohs' micrographic surgery (standard fresh-frozen technique). They remain disease-free 42 and 26 months after surgical excision, respectively. Mohs' micrographic surgery appears to be a rational and effective treatment for this uncommon malignancy.
我们报告了一名72岁女性,其右眉处有一个缓慢增大、无症状的囊性结节,以及一名66岁女性,其左下眼睑有一个红色结节性病变。对这两个肿瘤进行的切开活检显示真皮上皮细胞岛嵌入粘蛋白池中。肿瘤细胞细胞角蛋白7、雌激素和孕激素受体染色呈阳性,波形蛋白和S-100蛋白染色呈阴性。这些发现符合黏液癌的诊断。全面检查排除了原发性内脏黏液癌的皮肤转移。为确保肿瘤完全切除,两名患者均接受了莫氏显微外科手术(标准新鲜冷冻技术)。手术切除后分别42个月和26个月,她们均无疾病复发。莫氏显微外科手术似乎是治疗这种罕见恶性肿瘤的合理且有效的方法。