Bryant Heather, Robson Paula J, Ullman Ruth, Friedenreich Christine, Dawe Ursula
Division of Population Health and Information, Alberta Cancer Board, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Chronic Dis Can. 2006;27(2):51-9.
In a climate of increasing privacy concerns, the feasibility of establishing new cohorts to examine chronic disease etiology has been debated. Our primary aim was to ascertain the feasibility of enrolling a geographically dispersed, population-based cohort in Alberta. We also examined whether enrolees would grant access to provincial health care utilization data and consider providing blood for future analysis. Using random digit dialling, 22,652 men and women aged 35 to 69 years, without diagnosed cancer, were recruited. Of these, 52.4 percent (N=11,865) enrolled; 84 percent of Alberta communities were represented. Approximately 97 percent of enrolees consented to linkage with health care data, and 91 percent indicated willingness to consider future blood sampling. Comparisons between the cohort and the Canadian Community Health Survey (Cycle 1.1) for Alberta demonstrated similarities in marital status and income. However, the cohort had a smaller proportion who had not finished high school, a greater proportion of nonsmokers and a higher prevalence of obesity. These findings indicate that establishment of a geographically dispersed cohort is feasible in the Canadian context, and that data linkage and biomarker studies may be viable.
在隐私问题日益受到关注的大环境下，建立新的队列来研究慢性病病因的可行性一直存在争议。我们的主要目的是确定在艾伯塔省招募一个地域分散、基于人群的队列的可行性。我们还研究了参与者是否会同意获取省级医疗保健利用数据，并考虑为未来的分析提供血液样本。通过随机数字拨号，招募了22652名年龄在35至69岁之间、未被诊断患有癌症的男性和女性。其中，52.4%（N = 11865）的人登记入组；代表了艾伯塔省84%的社区。约97%的入组者同意与医疗保健数据建立关联，91%的人表示愿意考虑未来的血液采样。该队列与加拿大社区健康调查（第1.1轮）中艾伯塔省的数据比较显示，在婚姻状况和收入方面存在相似之处。然而，该队列中未完成高中学业的比例较小，不吸烟者的比例较大，肥胖患病率较高。这些发现表明，在加拿大的背景下建立一个地域分散的队列是可行的，并且数据关联和生物标志物研究可能是可行的。
