School of Public Health, University of Alberta, Edmonton, AB T6G 1C9, Canada.
Nutrients. 2020 Aug 13;12(8):2437. doi: 10.3390/nu12082437.
Depression is a leading cause of disability and economic burden worldwide. Primary prevention strategies are urgently needed. We examined the association of diet quality with depression in a large provincial cohort of adults. A past year food frequency questionnaire was completed by Alberta's Tomorrow Project (ATP) participants enrolled between 2000-2008 ( = 25,016; average age 50.4 years) and used to calculate Healthy Eating Index-Canada (HEI-C) 2015 scores. The number of physician visits for depression 2000-2015 was obtained via linkage with administrative health records. Negative binomial regression models assessed the relationship between HEI-C 2015 scores and physician visits for depression, adjusting for confounders. Every 10-unit increase in HEI-C 2015 scores was associated with 4.7% fewer physician visits for depression (rate ratio (RR): 0.95; 95% Confidence Interval (CI): 0.92-0.98). This relationship persisted when participants with physician visits for mental illness prior to cohort enrollment were excluded. Higher quality diets were associated with a lower number of physician visits for depression. Results highlight diet may be an important prevention strategy for reducing the burden of health service utilization for depression.
抑郁症是全球范围内导致残疾和经济负担的主要原因。迫切需要制定初级预防策略。我们在一个大型省级成年人队列中研究了饮食质量与抑郁症之间的关系。阿尔伯塔省明天计划（ATP）的参与者在 2000-2008 年期间入组（n=25016；平均年龄 50.4 岁），完成了过去一年的食物频率问卷，并用于计算加拿大健康饮食指数 2015 评分（HEI-C）。通过与行政健康记录的链接获得了 2000-2015 年因抑郁症就诊的医生数量。采用负二项回归模型，调整混杂因素后，评估了 HEI-C 2015 评分与因抑郁症就诊的医生数量之间的关系。HEI-C 2015 评分每增加 10 个单位，因抑郁症就诊的医生数量就会减少 4.7%（相对风险比 (RR)：0.95；95%置信区间 (CI)：0.92-0.98）。当排除在队列入组前因精神疾病就诊的参与者后，这种关系仍然存在。更高质量的饮食与较少的因抑郁症就诊的医生数量相关。结果强调了饮食可能是减少抑郁症患者健康服务利用负担的重要预防策略。
