Localization of the reeler gene relative to flanking loci on mouse chromosome 5.

The location of the reeler (rl) locus in mice in the paracentromeric part of chromosome (Chr) 5, proximal to the T(5;12)31H translocation breakpoint, has been confirmed. Analysis of DNA from animals with different doses of the proximal part of Chr 5 and from congenic mice showed that the Pgy-1 locus is the closet marker to rl, whereas En-2 is located farther, distal to the T31H breakpoint. Together with recently published evidence (Martin et al. 1989), our data suggest the following order: Cen-rl/Pgy-1-T31H-En-2.