对小鼠免疫球蛋白重链基因和血清前白蛋白基因的连锁分析确定了它们在12号染色体上的位置，该位置靠近12F1带中的T(5;12)31H断点。
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.
作者信息
Meo T, Johnson J, Beechey C V, Andrews S J, Peters J, Searle A G
出版信息
Proc Natl Acad Sci U S A. 1980 Jan;77(1):550-3. doi: 10.1073/pnas.77.1.550.
Abstract
Analysis of backcross mice carrying the Harwell translocation T(5;12)31H has led to the definitive localization of the immunoglobulin heavy chain gene cluster. Both Igh-1 and Pre-1 loci were found to segregate in tight linkage with the chromosomal markers 5(12) and 12(5), which define the balanced translocation T(5;12)31H. Additional data establish the location of these genes at the telomeric end of chromosome 12. That both loci are proximal to the chromosomal breakpoint in band 12F1 is shown by the phenotypes of segregants aneuploid for the presence or absence of the small marker 5(12). The order of loci inferred from a single recovered recombinant is: centromere-Igh-1-Pre-1-T(5;12)31H.
摘要
对携带哈韦尔易位T(5;12)31H的回交小鼠进行分析，已明确了免疫球蛋白重链基因簇的定位。发现Igh-1和Pre-1基因座均与定义平衡易位T(5;12)31H的染色体标记5(12)和12(5)紧密连锁分离。其他数据确定了这些基因在12号染色体端粒末端的位置。对于存在或不存在小标记5(12)的非整倍体分离株的表型表明，这两个基因座均靠近12F1带中的染色体断点。从单个回收的重组体推断出的基因座顺序为：着丝粒-Igh-1-Pre-1-T(5;12)31H。
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Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.对小鼠免疫球蛋白重链基因和血清前白蛋白基因的连锁分析确定了它们在12号染色体上的位置，该位置靠近12F1带中的T(5;12)31H断点。
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Protein A from Staphylococcus aureus. Its isolation by affinity chromatography and its use as an immunosorbent for isolation of immunoglobulins.金黄色葡萄球菌的A蛋白。通过亲和层析法进行分离及其作为免疫吸附剂用于分离免疫球蛋白。
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Chromosomal radiosensitivity and karyotype in mice using cultured peripheral blood lymphocytes, and comparison with this system in man.利用培养的外周血淋巴细胞研究小鼠的染色体放射敏感性和核型，并与人类的该系统进行比较。
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