Abrashev Ignat, Orozova Petya
Bulgarian Academy of Sciences, Institute of Microbiology, Department of Microbial Biochemistry, 26 Acad. G. Bonchev str., 1113 Sofia, Bulgaria.
Z Naturforsch C J Biosci. 2006 May-Jun;61(5-6):434-8. doi: 10.1515/znc-2006-5-621.
The role of the enzyme neuraminidase in pathogenicity of the bacillus Erysipelothrix rhusiopathiae was studied. Different substances with low and high molecular weight were tested as inducers of E. rhusiopathiae neuraminidase biosynthesis. It was found that macromolecular complexes induce the secretion of the enzyme. K(M) values for different substrates showed that the affinity of the E. rhusiopathiae neuraminidase increases in parallel with the enlargement of the molecular weight of glycoproteins. Results from the rabbits skin test confirmed the role of E. rhusiopathiae neuraminidase as a factor of pathogenicity with spreading functions.
研究了神经氨酸酶在猪丹毒杆菌致病性中的作用。测试了不同分子量的低分子和高分子物质作为猪丹毒杆菌神经氨酸酶生物合成的诱导剂。发现大分子复合物可诱导该酶的分泌。不同底物的米氏常数（K(M)）表明，猪丹毒杆菌神经氨酸酶对糖蛋白的亲和力随着糖蛋白分子量的增大而平行增加。兔皮肤试验结果证实了猪丹毒杆菌神经氨酸酶作为具有扩散功能的致病因素的作用。
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