阿那曲唑治疗复发性卵巢成人颗粒细胞瘤：2例报告
Anastrozole therapy in recurrent ovarian adult granulosa cell tumors: a report of 2 cases.
作者信息
Freeman Stephanie A, Modesitt Susan C
机构信息
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Chandler Medical Center, Lexington, KY 40536-0298, USA.
出版信息
Gynecol Oncol. 2006 Nov;103(2):755-8. doi: 10.1016/j.ygyno.2006.06.022. Epub 2006 Jul 25.
BACKGROUND
Ovarian sex cord stromal tumors are frequently hormonally active, and adult granulosa cell tumors often demonstrate estrogen receptor positivity. Thus, hormonal agents have been evaluated as potential treatments for advanced stage or recurrent adult granulosa cell tumors.
CASE
Two cases of patients with recurrent adult granulosa cell tumors are presented. Each patient received multiple treatment modalities including chemotherapy and had previously progressed on leuprolide. Both patients were started on anastrozole with subsequent normalization of inhibin B levels and clinical exams. They have been maintained on treatment for 14 and 18 months, respectively, and have tolerated the drug without difficulty.
CONCLUSION
Aromatase inhibitors may be a viable treatment option for women with advanced stage or recurrent ovarian adult granulosa cell tumors.
背景
卵巢性索间质肿瘤通常具有激素活性，成人颗粒细胞瘤常表现为雌激素受体阳性。因此，激素药物已被评估为晚期或复发性成人颗粒细胞瘤的潜在治疗方法。
病例
本文报告两例复发性成人颗粒细胞瘤患者。每位患者都接受了包括化疗在内的多种治疗方式，且之前使用亮丙瑞林治疗时病情进展。两名患者均开始使用阿那曲唑治疗，随后抑制素B水平恢复正常，临床检查结果也正常。她们分别接受该药物治疗14个月和18个月，且耐受良好。
结论
芳香化酶抑制剂可能是晚期或复发性卵巢成人颗粒细胞瘤女性患者的一种可行治疗选择。
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