Abdul Munem Assam, Al-Bahrani Bassim, Mehdi Itrat, Kamona Atheel, Nadas Ayman Mohammad
Department of Medical Oncology, National Oncology Centre, Royal Hospital, Muscat, Sultanate of Oman.
J Pak Med Assoc. 2012 May;62(5):505-7.
Granulosa cell tumour of the ovary in adults is a rare tumour of low malignant potential affecting middle aged peri or post menopausal patients. These tumours are often diagnosed at an early stage, due to their hormonally active nature. They, however, have unique distinguishing histologic features and behaviour of frequent and late local or systemic relapses. The diagnosis can be challenging with unusual presentations. There is high association of endometrial carcinoma. Surgery is the mainstay of management in early low risk disease, while radiotherapy and systemic platinum based chemotherapy are employed in higher stage with poor prognostic indices. Survival is good in early stage disease. Recurrent, progressive, and treatment refractory disease is not infrequent and poses management challenge. Endocrine manipulation and hormone treatment are employed in few cases with equivocal results, as reported in literature. We present a case of recurrent and treatment refractory GCT in a postmenopausal patient, managed by aromatase inhibitor Anastrozole with reasonable efficacy.
成人卵巢颗粒细胞瘤是一种罕见的、恶性潜能较低的肿瘤，影响中年围绝经期或绝经后患者。由于其具有激素活性，这些肿瘤通常在早期被诊断出来。然而，它们具有独特的组织学特征，并且经常出现局部或全身复发且复发较晚。不寻常的表现可能会给诊断带来挑战。子宫内膜癌与之高度相关。对于早期低风险疾病，手术是主要的治疗方法，而对于预后指标较差的晚期疾病，则采用放疗和基于铂的全身化疗。早期疾病的生存率良好。复发性、进行性和治疗难治性疾病并不少见，给治疗带来挑战。如文献报道，少数病例采用内分泌调控和激素治疗，但效果不明确。我们报告一例绝经后复发性和治疗难治性颗粒细胞瘤患者，使用芳香化酶抑制剂阿那曲唑治疗，取得了合理疗效。
