Keskin Serkan, Bengisu Ergin, Tuzlali Sitki, Aydiner Adnan
Department of Medical Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey.
Onkologie. 2012;35(7-8):451-3. doi: 10.1159/000341078. Epub 2012 Jul 3.
Adult granulosa cell tumors (GCTs) are frequently hormonally active. Thus, hormonal agents have been evaluated for the treatment of advanced-stage or recurrent disease.
A 39-year-old patient presented with recurrent GCT. The patient received multiple treatment modalities, including surgery and 2 different chemotherapy regimens (cisplatin- and taxanebased). Abdominal computed tomography following these treatments showed local recurrence with multiple implants. The patient's inhibin B level increased to 187 pg/ml at this time. The patient was treated with leuprolide 11.25 mg every 3 months and tamoxifen 20 mg twice daily. The patient's inhibin B level began to decrease after 1 month and returned to normal after 4 months. The patient has been maintained on this treatment for 2 years and has tolerated the drugs well.
The combination of leuprolide and tamoxifen had limited side effects in the presented patient and might be a viable treatment option for women with advanced-stage or recurrent adult ovarian GCTs.
成人颗粒细胞瘤（GCTs）通常具有激素活性。因此，人们已对激素药物用于晚期或复发性疾病的治疗进行了评估。
一名39岁患者出现复发性颗粒细胞瘤。该患者接受了多种治疗方式，包括手术以及两种不同的化疗方案（基于顺铂和紫杉烷）。这些治疗后的腹部计算机断层扫描显示局部复发并伴有多处植入。此时患者的抑制素B水平升至187 pg/ml。患者接受每3个月注射11.25 mg亮丙瑞林以及每日两次口服20 mg他莫昔芬的治疗。1个月后患者的抑制素B水平开始下降，4个月后恢复正常。该患者一直维持这种治疗2年，对药物耐受性良好。
亮丙瑞林和他莫昔芬联合使用对该患者副作用有限，可能是晚期或复发性成人卵巢颗粒细胞瘤女性患者的一种可行治疗选择。
