Temesgen Zelalem, Cainelli Francesca, Poeschla Eric M, Vlahakis Stacey A R, Vento Sandro
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Lancet Infect Dis. 2006 Aug;6(8):496-507. doi: 10.1016/S1473-3099(06)70550-3.
Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
尽管高效抗逆转录病毒疗法使与艾滋病相关的发病率和死亡率大幅下降，但对接受过大量治疗的患者进行管理仍然复杂且具有挑战性。后续抗逆转录病毒治疗方案的治疗反应率低于初始抗逆转录病毒治疗。此外，多重耐药性艾滋病毒与死亡率增加有关。我们回顾了与此类患者管理相关的数据，并提供了一种构建挽救性抗逆转录病毒治疗方案的系统方法。
