Halie M R, Splett-Romascano M, Molenaar I, Nieweg H O
Acta Haematol. 1975;54(1):18-26. doi: 10.1159/000208046.
Investigations with the electron microscope on peripheral blood of patients with Hodgkin's disease revealed parallel tubular structures in the cytoplasm of the lymphocytes, similar to those described in the literature. In normal subjects 2-9% of the lymphocytes were found to contain these structures. The number of such lymphocytes is increased in most patients as compared to normals. A correlation between an increase of inclusions containing lymphocytes and the histological or clinical classifications could not be established. An elevation of lymphocytes with tubular structures could be found in both favourable and unfavourable histological and clinical subgroups of Hodgkin patients, but especially in all groups with an unfavourable prognosis. The origin and function of the parallel tubular structures is still unknown, but their increase in lymphocytes of patients with Hodgkin's disease is of some interest in view of the involvement of these cells.
用电子显微镜对霍奇金病患者外周血进行的研究显示，淋巴细胞胞质中存在平行管状结构，与文献中描述的结构相似。在正常受试者中，发现2%至9%的淋巴细胞含有这些结构。与正常人相比，大多数患者中此类淋巴细胞的数量增加。含有淋巴细胞的包涵体增加与组织学或临床分类之间未发现相关性。在霍奇金病患者组织学和临床预后良好及不良的亚组中均能发现含有管状结构的淋巴细胞增多，但在所有预后不良的组中尤为明显。平行管状结构的起源和功能尚不清楚，但鉴于这些细胞的受累情况，其在霍奇金病患者淋巴细胞中的增加值得关注。
