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与缺铁性贫血相关的淋巴细胞线粒体形态异常。

Morphological abnormalities in lymphocyte mitochondria associated with iron-deficiency anaemia.

作者信息

Jarvis J H, Jacobs A

出版信息

J Clin Pathol. 1974 Dec;27(12):973-9. doi: 10.1136/jcp.27.12.973.

DOI:10.1136/jcp.27.12.973
PMID:4375687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC475566/
Abstract

Morphological abnormalities in lymphocyte mitochondria of iron-deficient subjects are described. The abnormalities are of a degenerative type and are similar to those described in the mitochondria of other cells during iron deficiency.

摘要

本文描述了缺铁受试者淋巴细胞线粒体的形态学异常。这些异常属于退行性类型，与缺铁时其他细胞线粒体中所描述的异常相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/bc073d211c1a/jclinpath00134-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/a9aab49ece7e/jclinpath00134-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/1e3c4e4648e0/jclinpath00134-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/0ab8509e2447/jclinpath00134-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/9f1269e62178/jclinpath00134-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/d438ede8256d/jclinpath00134-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/a1c587b3c82e/jclinpath00134-0042-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/e754e8591ab6/jclinpath00134-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/0d82bbd15238/jclinpath00134-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/bc073d211c1a/jclinpath00134-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/a9aab49ece7e/jclinpath00134-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/1e3c4e4648e0/jclinpath00134-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/0ab8509e2447/jclinpath00134-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/9f1269e62178/jclinpath00134-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/d438ede8256d/jclinpath00134-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/a1c587b3c82e/jclinpath00134-0042-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/e754e8591ab6/jclinpath00134-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/0d82bbd15238/jclinpath00134-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b992/475566/bc073d211c1a/jclinpath00134-0044-a.jpg

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本文引用的文献

1
The ultrastructure of lymphocytes.淋巴细胞的超微结构。
Semin Hematol. 1969 Jan;6(1):4-27.
2
A method of preparing peripheral leucocytes for electron microscopy.
J Ultrastruct Res. 1965 Oct;13(3):263-8. doi: 10.1016/s0022-5320(65)80075-2.
3
Reduced bactericidal capacity of polymorphs in iron deficiency.缺铁状态下多形核白细胞杀菌能力降低。
Arch Dis Child. 1973 Nov;48(11):864-6. doi: 10.1136/adc.48.11.864.
μ阿片受体介导的内溶酶体铁释放会增加线粒体铁水平、活性氧水平并导致细胞死亡。
NeuroImmune Pharm Ther. 2023 Mar 25;2(1):19-35. doi: 10.1515/nipt-2022-0013. Epub 2022 Sep 14.
4
Mitochondrial Respiration in Response to Iron Deficiency Anemia: Comparison of Peripheral Blood Mononuclear Cells and Liver.缺铁性贫血状态下的线粒体呼吸：外周血单个核细胞与肝脏的比较
Metabolites. 2022 Mar 21;12(3):270. doi: 10.3390/metabo12030270.
5
Mitochondrial iron metabolism and neurodegenerative diseases.线粒体铁代谢与神经退行性疾病。
Neurotoxicology. 2022 Jan;88:88-101. doi: 10.1016/j.neuro.2021.11.003. Epub 2021 Nov 5.
6
Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice.骨髓特异性铁蛋白缺失会损害巨噬细胞的生物能量，但与成年小鼠的系统性胰岛素作用无关。
Am J Physiol Endocrinol Metab. 2021 Sep 1;321(3):E376-E391. doi: 10.1152/ajpendo.00116.2021. Epub 2021 Aug 2.
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