Titt U, Vassiliev O N, Pönisch F, Dong L, Liu H, Mohan R
M. D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Med Phys. 2006 Jun;33(6):1595-602. doi: 10.1118/1.2198327.
In principle, the concept of flat initial radiation-dose distribution across the beam is unnecessary for intensity modulated radiation therapy. Dynamic leaf positioning during irradiation could appropriately adjust the fluence distribution of an unflattened beam that is peaked in the center and deliver the desired uniform or nonuniform dose distribution. Removing the flattening filter could lead to reduced treatment time through higher dose rates and reduced scatter, because there would be substantially less material in the beam; and possibly other dosimetric and clinical advantages. This work aims to evaluate the properties of a flattening filter free clinical accelerator and to investigate its possible advantages in clinical intensity modulated radiation therapy applications by simulating a Varian 2100-based treatment delivery system with Monte Carlo techniques. Several depth-dose curves and lateral dose distribution profiles have been created for various field sizes, with and without the flattening filter. Data computed with this model were used to evaluate the overall quality of such a system in terms of changes in dose rate, photon and electron fluence, and reduction in out-of-field stray dose from the scattered components and were compared to the corresponding data for a standard treatment head with a flattening filter. The results of the simulations of the flattening filter free system show that a substantial increase in dose rate can be achieved, which would reduce the beam on time and decrease the out-of-field dose for patients due to reduced head-leakage dose. Also close to the treatment field edge, a significant improvement in out-of-field dose could be observed for small fields, which can be attributed to the change in the photon spectra, when the flattening filter is removed from the beamline.
原则上,对于调强放射治疗而言,射野初始剂量分布平坦的概念并非必要。在照射过程中动态调整准直器叶片位置,能够适当地调整未加均整滤过器的射束注量分布,该射束在中心处剂量率最高,并能产生所需的均匀或非均匀剂量分布。去除均整滤过器可提高剂量率并减少散射,从而缩短治疗时间,因为射束中的物质会大幅减少;此外还可能带来其他剂量学和临床优势。本研究旨在通过蒙特卡罗技术模拟基于瓦里安2100的治疗输送系统,评估无均整滤过器临床加速器的性能,并研究其在临床调强放射治疗应用中的潜在优势。针对有无均整滤过器的不同射野大小,已生成了多条深度剂量曲线和侧向剂量分布剖面图。利用该模型计算得到的数据,从剂量率变化、光子和电子注量以及散射分量导致的射野外散射剂量减少等方面,评估了此类系统的整体质量,并与带有均整滤过器的标准治疗头的相应数据进行了比较。无均整滤过器系统的模拟结果表明,剂量率可大幅提高,这将减少射束开启时间,并因头部漏射线剂量降低而减少患者的射野外剂量。在靠近治疗射野边缘处,对于小射野可观察到射野外剂量有显著改善,这可归因于从射束路径中移除均整滤过器时光子能谱的变化。