Cashmore Jason
University Hospital Birmingham NHS Foundation Trust, UK.
Phys Med Biol. 2008 Apr 7;53(7):1933-46. doi: 10.1088/0031-9155/53/7/009. Epub 2008 Mar 11.
Commissioning data have been measured for an Elekta Precise linear accelerator running at 6 MV without a flattening filter with the aim of studying the effects of flattening filter removal on machine operation and beam characterization. Modern radiotherapy practice now routinely relies on the use of fluence modifying techniques such as IMRT, i.e. the active production of non-flat beams. For these techniques the flattening filter should not be necessary. It is also possible that the increased intensity around the central axis associated with unflattened beams may be useful for conventional treatment planning by acting as a field-in-field or integrated boost technique. For this reason open and wedged field data are presented. Whilst problems exist in running the machine filter free clinically, this paper shows that in many ways the beam is actually more stable, exhibiting almost half the variation in field symmetry for changes in steering and bending currents. Dosimetric benefits are reported here which include a reduction in head scatter by approx. 70%, decreased penumbra (0.5 mm), lower dose outside of the field edge (11%) and a doubling in dose rate (2.3 times for open and 1.9 times for wedged fields). Measurements also show that reduced scatter also reduces leakage radiation by approx. 60%, significantly lowering whole body doses. The greatest benefit of filter-free use is perceived to be for IMRT where increased dose rate combined with reduced head scatter and leakage radiation should lead to improved dose calculation, giving simpler, faster and more accurate dose delivery with reduced dose to normal tissues.
已针对一台运行于6兆伏、不带均整器的医科达Precise直线加速器测量了调试数据,目的是研究去除均整器对机器运行和射束特性的影响。现代放射治疗实践现在通常依赖于使用如调强放射治疗(IMRT)等注量修正技术,即主动生成非平坦射束。对于这些技术,均整器应该是不必要的。与未均整射束相关的中心轴周围强度增加,也有可能作为一种野中野或累积加量技术,对传统治疗计划有用。因此,给出了开放野和楔形野数据。虽然在临床运行无均整器的机器时存在问题,但本文表明,在许多方面射束实际上更稳定,对于转向和弯曲电流变化,其射野对称性变化几乎减半。本文报道了剂量学益处,包括头部散射减少约70%、半值层减小(0.5毫米)、射野外剂量降低(11%)以及剂量率翻倍(开放野为2.3倍,楔形野为1.9倍)。测量还表明,散射减少也使泄漏辐射减少约60%,显著降低全身剂量。无均整器使用的最大益处被认为在于调强放射治疗,剂量率增加以及头部散射和泄漏辐射减少应能改善剂量计算,实现更简单、更快且更准确的剂量输送,同时减少对正常组织的剂量。