Chamorro García L
Servicio de Psiquiatría, Hospital General, Insalud de Guadalajara.
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1991 Nov-Dec;19(6):298-303.
This report concerns two schizophrenic patients who had ingested a biperiden overdose between 8 and 14 mg per day. This drug had been prescribed to treat extrapyramidal side effects of neuroleptics. Once the ingestion was suppressed, both patients complained about anxiety, discomfort and depression. These symptoms disappeared when reintroducing the biperiden. Both patients had a previous record of alcohol and cannabis abuse. One of them had also a recorder of sporadic consumption of other drugs such as heroin, amphetamines and hallucinogens. The predominant psychopathology was of the negative type. Through these cases we intend to support the likelihood of a cholinergic hyperactivity in the negative schizophrenic symptoms.
本报告涉及两名精神分裂症患者，他们每天摄入8至14毫克的过量比哌立登。该药物被用于治疗抗精神病药物的锥体外系副作用。一旦停止摄入，两名患者均抱怨出现焦虑、不适和抑郁。重新引入比哌立登后，这些症状消失。两名患者既往均有酒精和大麻滥用史。其中一人还曾有过偶尔使用海洛因、苯丙胺和致幻剂等其他药物的记录。主要的精神病理学表现为阴性类型。通过这些病例，我们旨在支持阴性精神分裂症症状中存在胆碱能功能亢进的可能性。
