Takeuchi Tomoyo, Minami Yuko, Iijima Tatsuo, Kameya Toru, Asamura Hisao, Noguchi Masayuki
Department of Pathology, Institute of Basic Medical Science, University of Tsukuba, Tsukuba, and Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Pathol Int. 2006 Aug;56(8):434-9. doi: 10.1111/j.1440-1827.2006.01985.x.
Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2% in LCNEC, 81.8% in SCLC, 50.0% in LCC and 7.14% in CT. Those at 22q13.3 were 30.8% in LCNEC, 72.7% in SCLC, 45.5% in LCC and 7.14% in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6%) was significantly higher than that of LCNEC (15.4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.
肺大细胞神经内分泌癌（LCNEC）是一种新的实体。除形态学特征外，许多研究人员对其分子生物学特征进行了研究，并与其他神经内分泌癌、小细胞肺癌（SCLC）和类癌肿瘤（CT）进行了比较。然而，很少有报告显示它们之间存在显著不同的遗传特征。本文的目的是研究38例肺神经内分泌癌（13例LCNEC、11例SCLC和14例CT）和10例大细胞癌（LCC）中3号染色体p臂（3p14.2）杂合性缺失（LOH）的频率。3p14.2处的LOH频率在LCNEC中为69.2%，在SCLC中为81.8%，在LCC中为50.0%，在CT中为7.14%。22q13.3处的频率在LCNEC中为30.8%，在SCLC中为72.7%，在LCC中为45.5%，在CT中为7.14%。特别是，3p14.2和22q13.3均存在LOH的SCLC频率（63.6%）显著高于LCNEC（15.4%）。LCNEC和SCLC在3p14.2和22q13.3处具有不同的LOH模式特征。3p14.2和22q13.3处LOH的联合分析被认为有助于LCNEC和SCLC的鉴别诊断。
