筛选分泌哈尔满的微藻，哈尔满是一种具有多种生物活性的吲哚生物碱。

Screening of microalgae for species excreting norharmane, a manifold biologically active indole alkaloid.

作者信息

Volk Rainer-B

机构信息

Department of Pharmaceutical Biology, University of Kiel, Pharmaceutical Institute, Kiel, Germany.

出版信息

Microbiol Res. 2008;163(3):307-13. doi: 10.1016/j.micres.2006.06.002. Epub 2006 Jul 26.

DOI:10.1016/j.micres.2006.06.002

PMID:16872816

Abstract

A screening of microalgae strains is described, with the objective to discover more species besides the known cyanobacterium Nodularia harveyana which excrete the manifold biologically active and co-mutagenic indole alkaloid norharmane (9H-pyrido(3,4-b)indole) into their environment. Seven more cyanobacterial species, Anabaena cylindrica, Anabaena inaequalis, Anabaenopsis siamensis, Chroococcus minutus, Nostoc carneum, Nostoc commune and Phormidium foveolarum, were newly discovered. The norharmane concentrations detected for cyanobacterial culture media varied in a species-dependent manner from less than 1 up to 525 microg l(-1). The risk for humans and livestock, resulting from the natural appearance of norharmane as an extracellular metabolite of various cyanobacteria, is discussed.

摘要

本文描述了对微藻菌株的筛选，目的是发现除已知的哈氏节旋藻（Nodularia harveyana）之外更多能向环境中分泌多种具有生物活性和共诱变作用的吲哚生物碱去甲哈尔满（9H-吡啶并[3,4-b]吲哚）的物种。另外新发现了7种蓝藻物种，分别是圆柱鱼腥藻（Anabaena cylindrica）、不等鱼腥藻（Anabaena inaequalis）、暹罗拟鱼腥藻（Anabaenopsis siamensis）、微小色球藻（Chroococcus minutus）、肉色念珠藻（Nostoc carneum）、普通念珠藻（Nostoc commune）和窝形席藻（Phormidium foveolarum）。检测到的蓝藻培养基中的去甲哈尔满浓度因物种而异，范围从低于1微克/升到525微克/升。本文还讨论了各种蓝藻自然产生的去甲哈尔满作为细胞外代谢产物对人类和牲畜造成的风险。