Annels S J, Ellis Y, Davies J A
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Brain Res. 1991 Nov 15;564(2):341-3. doi: 10.1016/0006-8993(91)91474-f.
The non-opioid antitussive drugs, dextromethorphan, caramiphen and carbetapentane, are also anticonvulsant. The effects of these antitussives on potassium-stimulated release of endogenous amino acids from rabbit hippocampal slices was tested. All 3 drugs significantly reduced the release of glutamate, with carbetapentane being the most potent (IC50 approximately 40 microM). We suggest that the anticonvulsant action may be due to their ability to decrease glutamate release.
非阿片类镇咳药右美沙芬、卡拉美芬和卡比沙明也具有抗惊厥作用。我们测试了这些镇咳药对钾刺激兔海马切片释放内源性氨基酸的影响。这三种药物均能显著降低谷氨酸的释放，其中卡比沙明作用最强（半数抑制浓度约为40微摩尔）。我们认为其抗惊厥作用可能是由于它们能够减少谷氨酸的释放。
