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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Domenici M R, Sagratella S, Frank C, Scotti de Carolis A

Pharmacology Department, Istituto Superiore di Sanita, Roma, Italy.

Gen Pharmacol. 1993 Jul;24(4):991-8. doi: 10.1016/0306-3623(93)90178-z.

The effects of the non-opioid antitussives caramiphen and carbetapentane and of the anticonvulsants 5,5-diphenylhydantoin and MK 801 were tested towards hypoxia-induced electrical changes in rat hippocampal slices. 2. The incidence of appearance of hypoxia-induced epileptiform bursting was significantly decreased (P < 0.05) by carbetapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and the glutamate antagonist dizocilpine (MK 801, 25-50 microM). 3. The incidence of reappearance of the CA1 population spike after hypoxia was significantly increased (P < 0.05) by carbentapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and MK 801 (25-50 microM). 4. The results suggest a useful role for non-opioid antitussives and some anticonvulsants in the treatment of hypoxia-induced functional disturbances.

测试了非阿片类镇咳药卡拉美芬和卡比沙明以及抗惊厥药5,5-二苯基乙内酰脲和MK 801对大鼠海马切片缺氧诱导的电变化的影响。2. 卡比沙明（50 - 100微摩尔）、卡拉美芬（50 - 100微摩尔）、5,5-二苯基乙内酰脲（25 - 50微摩尔）和谷氨酸拮抗剂地佐环平（MK 801，25 - 50微摩尔）可使缺氧诱导的癫痫样爆发的发生率显著降低（P < 0.05）。3. 卡比沙明（50 - 100微摩尔）、卡拉美芬（50 - 100微摩尔）、5,5-二苯基乙内酰脲（25 - 50微摩尔）和MK 801（25 - 50微摩尔）可使缺氧后CA1群体峰电位的再现发生率显著增加（P < 0.05）。4. 结果表明非阿片类镇咳药和一些抗惊厥药在治疗缺氧诱导的功能障碍中具有有益作用。

Domenici M R, Sagratella S, Frank C, Scotti de Carolis A

Pharmacology Department, Istituto Superiore di Sanita, Roma, Italy.

Gen Pharmacol. 1993 Jul;24(4):991-8. doi: 10.1016/0306-3623(93)90178-z.

The effects of the non-opioid antitussives caramiphen and carbetapentane and of the anticonvulsants 5,5-diphenylhydantoin and MK 801 were tested towards hypoxia-induced electrical changes in rat hippocampal slices. 2. The incidence of appearance of hypoxia-induced epileptiform bursting was significantly decreased (P < 0.05) by carbetapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and the glutamate antagonist dizocilpine (MK 801, 25-50 microM). 3. The incidence of reappearance of the CA1 population spike after hypoxia was significantly increased (P < 0.05) by carbentapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and MK 801 (25-50 microM). 4. The results suggest a useful role for non-opioid antitussives and some anticonvulsants in the treatment of hypoxia-induced functional disturbances.

测试了非阿片类镇咳药卡拉美芬和卡比沙明以及抗惊厥药5,5-二苯基乙内酰脲和MK 801对大鼠海马切片缺氧诱导的电变化的影响。2. 卡比沙明（50 - 100微摩尔）、卡拉美芬（50 - 100微摩尔）、5,5-二苯基乙内酰脲（25 - 50微摩尔）和谷氨酸拮抗剂地佐环平（MK 801，25 - 50微摩尔）可使缺氧诱导的癫痫样爆发的发生率显著降低（P < 0.05）。3. 卡比沙明（50 - 100微摩尔）、卡拉美芬（50 - 100微摩尔）、5,5-二苯基乙内酰脲（25 - 50微摩尔）和MK 801（25 - 50微摩尔）可使缺氧后CA1群体峰电位的再现发生率显著增加（P < 0.05）。4. 结果表明非阿片类镇咳药和一些抗惊厥药在治疗缺氧诱导的功能障碍中具有有益作用。