多巴胺能受体亚型在小鼠僵尾行为中的作用

Involvement of dopaminergic receptor subtypes in straub tail behaviour in mice.

Zarrindast M R, Bayat A, Shafaghi B

Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Gen Pharmacol. 1993 Jan;24(1):127-30. doi: 10.1016/0306-3623(93)90022-p.

Abstract

Administration of apomorphine to mice induced straub tail behaviour dose-dependently. The response was decreased by the D1 antagonist SCH 23390, the D2 antagonist sulpiride. Reserpine plus alpha-methyl-p-tyrosine (AMPT), caused a marked increase in the response of the drug. 2. The D1 agonist SKF 38393 induced the straub tail behaviour in a dose-dependent manner, which was decreased by SCH 23390, sulpiride or reserpine + AMPT. 3. When animals were administered the D2 agonist quinpirole, a dose-dependent response was produced. This effect was decreased by sulpiride and reserpine + AMPT, but not by SCH 23390. 4. In animals pretreated with reserpine + AMPT, the combination of SKF 38393 with quinpirole produced a significant straub tail behaviour. 5. It is concluded that the concurrent D1/D2 dopamine receptor stimulation is necessary to produce straub tail behaviour in mice.

摘要

给小鼠注射阿扑吗啡会剂量依赖性地诱发弓背行为。D1拮抗剂SCH 23390、D2拮抗剂舒必利可降低该反应。利血平加α-甲基对酪氨酸（AMPT）会使药物反应显著增强。2. D1激动剂SKF 38393会剂量依赖性地诱发弓背行为，该行为会被SCH 23390、舒必利或利血平+AMPT降低。3. 给动物注射D2激动剂喹吡罗时，会产生剂量依赖性反应。该效应会被舒必利和利血平+AMPT降低，但不会被SCH 23390降低。4. 在经利血平+AMPT预处理的动物中，SKF 38393与喹吡罗联合使用会产生显著的弓背行为。5. 得出结论，同时刺激D1/D2多巴胺受体对于在小鼠中产生弓背行为是必要的。