通过自由基途径从天然α-氨基酸合成γ-氨基酸类似物。
Synthesis of gamma-amino acid analogues from natural alpha-amino acids by a radical pathway.
作者信息
Corvo M C, Pereira M M A
机构信息
REQUIMTE/CQFB, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal.
出版信息
Amino Acids. 2007 Feb;32(2):243-6. doi: 10.1007/s00726-006-0378-y. Epub 2006 Aug 2.
PMID:16874465
Abstract
New gamma-amino esters and amides were prepared by a radical 1,4-addition of carbon radicals to acrylic derivatives. Alpha-amino acids derivatives holding chiral auxiliaries as radical precursors and different chiral olefins were used and chiral induction on the C-gamma center was discussed.
摘要
通过碳自由基对丙烯酸衍生物的自由基1,4-加成反应制备了新型γ-氨基酯和酰胺。使用了带有手性助剂作为自由基前体的α-氨基酸衍生物和不同的手性烯烃，并讨论了在γ-碳中心上的手性诱导作用。
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