Renaud A, Nishino S, Dement W C, Guilleminault C, Mignot E
Sleep Research Center, Stanford University School of Medicine, Palo Alto, CA 94304.
Eur J Pharmacol. 1991 Nov 19;205(1):11-6. doi: 10.1016/0014-2999(91)90763-g.
Canine narcolepsy is an animal model of the human rapid eye movement sleep disorder. Dogs exhibit bouts of sleep attacks and muscle atonia (cataplexy) that are induced by emotions and thought to be abnormal rapid eye movement sleep episodes. We have previously demonstrated that cataplexy is strongly inhibited by increases in noradrenergic activity. This effect is mediated through central alpha 1-adrenoceptors, presumably of the alpha 1B subtype. In this study, we demonstrate with the canine model that SDZ NVI-085, a new compound with alerting effects, is a potent anticataplectic agent that may act through stimulation of an alpha 1-adrenoceptor subtype.
犬发作性睡病是人类快速眼动睡眠障碍的一种动物模型。狗会出现睡眠发作和肌肉张力缺失（猝倒），这些症状由情绪诱发，被认为是异常的快速眼动睡眠发作。我们之前已经证明，去甲肾上腺素能活性的增加会强烈抑制猝倒。这种作用是通过中枢α1肾上腺素能受体介导的，推测为α1B亚型。在本研究中，我们用犬模型证明，具有唤醒作用的新化合物SDZ NVI - 085是一种有效的抗猝倒剂，可能通过刺激α1肾上腺素能受体亚型发挥作用。
