前列腺素E2及其甲酯可减轻犬发作性睡病中的猝倒症状。
Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.
作者信息
Nishino S, Mignot E, Fruhstorfer B, Dement W C, Hayaishi O
机构信息
Sleep Disorders Center, Stanford University School of Medicine, Palo Alto, CA 94304.
出版信息
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2483-7. doi: 10.1073/pnas.86.7.2483.
The effects of intravenous administration of prostaglandins (PGs) were investigated in genetically narcoleptic Doberman pinschers. The treatment of narcoleptic dogs with PGE2 and PGE2 methyl ester, but not PGD2 and PGD2 methyl ester, induced a dose-dependent reduction of canine cataplexy, a dissociated manifestation of rapid-eye-movement sleep. The effect was specific and not associated with any change in other behavior. Furthermore, the effect was long-lasting (up to 2 hr) and could not be explained by the acute cardiovascular changes seen after intravenous PG administration. PGE2 methyl ester, a lipophilic derivative of PGE2 with more central penetration than PGE2, was 4 times more potent than PGE2. These results indicate that PGE2 modifies cataplexy through a central effect and suggest that this prostaglandin may play a role in rapid-eye-movement sleep regulation.
在遗传性发作性睡病的杜宾犬中研究了静脉注射前列腺素（PGs）的作用。用前列腺素E2（PGE2）和PGE2甲酯治疗发作性睡病犬，而非前列腺素D2（PGD2）和PGD2甲酯，可诱导犬猝倒症呈剂量依赖性减少，猝倒症是快速眼动睡眠的一种分离表现。该作用具有特异性，且与其他行为的任何变化无关。此外，该作用持久（长达2小时），不能用静脉注射PG后所见的急性心血管变化来解释。PGE2甲酯是PGE2的亲脂性衍生物，比PGE2具有更强的中枢穿透力，其效力是PGE2的4倍。这些结果表明，PGE2通过中枢作用改变猝倒症，并提示这种前列腺素可能在快速眼动睡眠调节中发挥作用。
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