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Effects of plumbagin on development of the parasitic nematodes Haemonchus contortus and Ascaris suum.

作者信息

Fetterer R H, Fleming M W

机构信息

Helminthic Diseases Laboratory, Livestock and Poultry Sciences Institute, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;100(3):539-42. doi: 10.1016/0742-8413(91)90036-s.

DOI:10.1016/0742-8413(91)90036-s
PMID:1687553
Abstract
  1. Plumbagin (5-hydroxy,2-methyl-1,4-napthoquinone) inhibited the motility and survival of Haemonchus contortus first-stage larvae (L1) with an ED50 of 1 microgram/ml, but was less effective in preventing the development of H. contortus to infective third-stage larvae in a faecal slurry assay. 2. Of the structural analogs tested, plumbagin was the most potent in preventing development of L1 followed in decreasing order of potency by 1,4-naphthoquinone, 5-hydroxy-1,4-napthoquinone (juglone) and 1,2-napthoquinone. 3. Plumbagin had a biphasic effect on development of the fourth-stage Ascaris suum larvae that caused an increase in growth at low concentrations but was lethal at higher doses. 4. Plumbagin and 1,2-napthoquinone partially inhibited embryonation of A. suum eggs.
摘要

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