Radkowski M, Laskus T, Kopicz-Kamińska E, Mian M, Babiuch L, Slusarczyk J
Zakład Immunopatologii, Instytut Chorób Zakaźnych i Pasozytniczych Akademii Medycznej w Warszawie.
Pol Arch Med Wewn. 1991 Oct;86(4):247-53.
Sequential changes of percentage and number of T4 (helper) and T8 (cytotoxic/suppressor) lymphocyte subsets and serum beta 2 microglobulin (beta 2m) level were observed in 23 HIV infected patients for a period of 4 months to 3 years. 10 subjects were asymptomatic HIV carriers, 9 had already AIDS at the beginning of the study and 4 patients developed clinically overt disease during the observation period. T4 lymphocyte number remained in normal range in asymptomatic HIV carriers but in 4 patients its decrease preceded the development of clinical symptoms of infection. A rapid decrease of T4 lymphocyte number was generally observed in AIDS patients. Serum concentration of beta 2m remained at relatively low and constant level in asymptomatic HIV carriers but in 4 cases its increase preceded the appearance of clinical symptoms. In patients with clinically overt disease beta 2m levels were significantly increased and reached the highest values just before death. A correlation between clinical stage of infection and the number of T4 lymphocytes and beta 2 m level was found.
对23例HIV感染患者进行了4个月至3年的观察，以观察T4（辅助性）和T8（细胞毒性/抑制性）淋巴细胞亚群的百分比和数量以及血清β2微球蛋白（β2m）水平的连续变化。10名受试者为无症状HIV携带者，9名在研究开始时已患有艾滋病，4名患者在观察期内出现了临床显性疾病。无症状HIV携带者的T4淋巴细胞数量保持在正常范围内，但4名患者的T4淋巴细胞数量在感染临床症状出现之前就有所下降。艾滋病患者通常观察到T4淋巴细胞数量迅速下降。无症状HIV携带者的血清β2m浓度保持在相对较低且恒定的水平，但4例患者的β2m浓度在临床症状出现之前就有所升高。在临床显性疾病患者中，β2m水平显著升高，并在死亡前达到最高值。发现感染的临床阶段与T4淋巴细胞数量和β2m水平之间存在相关性。
