Spanaki A, Linardakis E, Perdikogianni C, Stiakaki E, Morotti A, Cilloni D, Kalmanti M
Leuk Res. 2007 Apr;31(4):570-2. doi: 10.1016/j.leukres.2006.03.030. Epub 2006 Jul 31.
The purpose of this study was to investigate WT1 expression levels in childhood acute leukemia. Bone marrow from 14 children with acute leukemia at diagnosis and from 7 children with solid tumors without bone marrow involvement (control group) was studied. Five of the 14 patients (35.7%), expressed high levels of WT1. Four of the five WT1 positive patients with additional adverse prognostic factors, have succumbed to their disease. The results of this study are in accordance with the fact that high levels of WT1 expression have been reported in patients with an unfavorable outcome.
本研究的目的是调查儿童急性白血病中WT1的表达水平。研究了14例急性白血病患儿诊断时的骨髓样本以及7例无骨髓受累的实体瘤患儿（对照组）的骨髓样本。14例患者中有5例（35.7%）表达高水平的WT1。5例WT1阳性患者中有4例伴有其他不良预后因素，均已死于该疾病。本研究结果与报道中预后不良患者WT1表达水平高这一事实相符。
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