儿童肿瘤研究组报告：诊断时WT1表达不能预测儿童急性髓系白血病的生存情况。
WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.
作者信息
Noronha Suzie A, Farrar Jason E, Alonzo Todd A, Gerbing Robert B, Lacayo Norman J, Dahl Gary V, Ravindranath Yaddanapudi, Arceci Robert J, Loeb David M
机构信息
Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.
出版信息
Pediatr Blood Cancer. 2009 Dec;53(6):1136-9. doi: 10.1002/pbc.22142.
Abstract
WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.
摘要
WT1是一种转录因子，在急性和慢性白血病中异常过度表达。已有报道称WT1在儿童急性髓系白血病中过度表达，但由于这些研究中的样本量相对较小，其预后意义尚不清楚。采用定量逆转录聚合酶链反应（qRT-PCR）检测了155例接受协作组方案治疗的儿童急性髓系白血病患者诊断时所取样本中的WT1表达。总生存期和无事件生存期均与WT1表达无关。
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