Hu Shao-Yan, Gu Wei-Ying, Chen Zi-Xing, Wang Xu-Li, Cen Jian-Nong, He Hai-Long, Chai Yi-Huan, Chen Chien-Shing
Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou City, China.
Pediatr Hematol Oncol. 2010 Nov;27(8):581-91. doi: 10.3109/08880011003762994.
WT1 (Wilms' tumor gene 1) overexpression is implicated in the prognosis of acute leukemia. The purpose of this study was to investigate WT1 expression and its clinical implication in childhood acute leukemia (AL) in Chinese population. Bone marrow specimen from 200 children at different stages of acute leukemia and from 21 children without leukemia were studied. The WT1 expression at diagnostic marrow specimen in both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) was higher than control group, whereas WT1 expression in AML was higher than in ALL, and WT1 expression level in relapse in ALL increased more significantly than in AML. The WT1 expression level showed positive correlation with the hypodiploidy and BCR-ABL fusion gene in acute leukemia. A rapidly decrease of WT1 expression level predicted a good response to the induction therapy and low expression of WT1 correlates with remission status. This study suggested that WT1 expression levels in acute leukemia can potentially be a marker for evaluating therapeutic efficacy, correlating with monitoring minimal residue disease, and predicting hematological relapse in children acute leukemia.
WT1（威尔姆斯瘤基因1）过表达与急性白血病的预后有关。本研究旨在调查中国人群中儿童急性白血病（AL）中WT1的表达及其临床意义。对200例处于不同阶段的急性白血病儿童以及21例无白血病儿童的骨髓标本进行了研究。急性髓系白血病（AML）和急性淋巴细胞白血病（ALL）诊断时骨髓标本中的WT1表达均高于对照组，而AML中的WT1表达高于ALL，ALL复发时WT1表达水平的升高比AML更显著。WT1表达水平与急性白血病中的亚二倍体和BCR-ABL融合基因呈正相关。WT1表达水平的快速下降预示着对诱导治疗有良好反应，WT1低表达与缓解状态相关。本研究表明，急性白血病中的WT1表达水平可能成为评估治疗效果、与监测微小残留病相关以及预测儿童急性白血病血液学复发的标志物。
