Constantinou Maria, Binka-Kowalska Aleksandra, Borkowska Edyta, Zajac Ewa, Jałmuzna Paweł, Matych Józef, Nawrocka Agnieszka, Kałuzewski Bogdan
Department of Medical Genetics, Medical University of Łódź, Sterlinga 1/3, 91-425 Lodz, Poland.
J Appl Genet. 2006;47(3):273-5. doi: 10.1007/BF03194636.
Multiplex FISH (UroVysion), Comparative Genomic Hybridization (CGH), and Multitemperature Single-Strand Conformation Polymorphism (MSSCP) were applied for non-invasive diagnosis and prognosis of bladder cancer. The UroVysion test was positive in 80% of patients with pT1 and in 100% of patients with either pT2 or pT3 tumours. Tumours with pT3T4 stages were characterized by high numbers of chromosomal imbalances, detected by CGH. The mutation of the p53 gene was detected in 16% of patients, but only in those with pT2 or pT3 tumours.
多重荧光原位杂交（UroVysion）、比较基因组杂交（CGH）和多温度单链构象多态性（MSSCP）被应用于膀胱癌的非侵入性诊断和预后评估。UroVysion检测在80%的pT1期患者以及100%的pT2或pT3期肿瘤患者中呈阳性。CGH检测发现，pT3T4期肿瘤的染色体不平衡数量较多。16%的患者检测到p53基因的突变，但仅在pT2或pT3期肿瘤患者中出现。
