Honda K, Hatayama T, Takahashi K, Yukioka M
Department of Biochemistry, Osaka City University Medical School, Japan.
Teratog Carcinog Mutagen. 1991;11(5):235-44. doi: 10.1002/tcm.1770110503.
In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride. In dispersed cells of the whole mouse embryo on the 11th day of development, heat shock proteins (hsp73 and hsp105) were induced by a heat shock or by exposure to sodium arsenite, but not by exposure to cadmium chloride. After a maternal hyperthermia or an intraperitoneal injection of sodium arsenite or cadmium chloride into a pregnant mouse, heat shock proteins accumulated in the embryo on the 9th day of development, especially in the neuroepithelial tissue. The significance of heat shock proteins in the embryo is discussed.
在正常妊娠10 - 17周的人绒毛膜绒毛组织中，热休克蛋白（hsp70、hsp73、hsp85和hsp105）可通过热休克或暴露于亚砷酸钠或氯化镉在体外诱导产生。在发育第11天的全小鼠胚胎分散细胞中，热休克蛋白（hsp73和hsp105）可通过热休克或暴露于亚砷酸钠诱导产生，但不能通过暴露于氯化镉诱导产生。在给怀孕小鼠进行母体高温处理或腹腔注射亚砷酸钠或氯化镉后，热休克蛋白在发育第9天的胚胎中积累，尤其是在神经上皮组织中。文中讨论了热休克蛋白在胚胎中的意义。
