Güngör Emre Sinan, Danişman Nuri, Mollamahmutoğlu Leyla
Zekai Tahir Burak Women's Health and Research Hospital, Ankara, Turkey.
Clin Chem Lab Med. 2006;44(8):974-7. doi: 10.1515/CCLM.2006.173.
During normal pregnancy, plasma concentrations of creatinine and uric acid normally decrease as a consequence of their increased glomerular filtration. Hyperuricemia in pregnant women has been associated with several pregnancy complications. We researched the relationship between serum uric acid, creatinine and albumin levels in pregnant women with normal glucose tolerance and gestational diabetes mellitus.
A total of 112 patients were evaluated, 56 of whom had gestational diabetes. All of the patients had single estimations of serum uric acid, creatinine, albumin and liver enzymes carried out on booking between the 24th and 28th gestational weeks. The women were followed up throughout pregnancy.
Significant differences were found between the two groups for maternal age, gravida, parity and maternal weight gain during pregnancy, but not for body mass index or blood pressure. Creatinine levels were significantly higher in the diabetic group than in the control group [0.6+/-0.15 vs. 0.43+/-0.1 mg/dL (53.04+/-13.26 micromol/L vs. 38.01+/-8.84 micromol/L), p<0.001]. Uric acid levels were also higher in the diabetic patients, but this elevation was not statistically significant [4.42+/-1.09 vs. 4.1+/-0.84 mg/dL (260.78+/-64.31 micromol/L vs. 241.49+/-49.56 micromol/L), p>0.05]. There were no differences in mean albumin concentrations or liver function tests.
In this prospective study of Turkish women, we found that patients with gestational diabetes had significantly higher levels of creatinine than normal pregnant women.
在正常妊娠期间，由于肾小球滤过增加，肌酐和尿酸的血浆浓度通常会降低。孕妇高尿酸血症与多种妊娠并发症有关。我们研究了糖耐量正常和妊娠期糖尿病孕妇血清尿酸、肌酐和白蛋白水平之间的关系。
共评估了112例患者，其中56例患有妊娠期糖尿病。所有患者在妊娠第24至28周登记时进行了血清尿酸、肌酐、白蛋白和肝酶的单次测定。这些妇女在整个孕期接受随访。
两组在产妇年龄、孕次、产次和孕期体重增加方面存在显著差异，但在体重指数或血压方面无差异。糖尿病组的肌酐水平显著高于对照组[0.6±0.15 vs. 0.43±0.1mg/dL(53.04±13.26μmol/L vs. 38.01±8.84μmol/L)，p<0.001]。糖尿病患者的尿酸水平也较高，但这种升高无统计学意义[4.42±1.09 vs. 4.1±0.84mg/dL(260.78±64.31μmol/L vs. 241.49±49.56μmol/L)，p>0.05]。平均白蛋白浓度或肝功能检查无差异。
在这项对土耳其女性的前瞻性研究中，我们发现妊娠期糖尿病患者的肌酐水平显著高于正常孕妇。
