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低剂量线谱和全谱紫外线对人血主要体液成分的影响。

Effect of Low-Dose Line-Spectrum and Full-Spectrum UV on Major Humoral Components of Human Blood.

机构信息

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky av., 31, 119991 Moscow, Russia.

Department of Plasma Power Plants, Bauman Moscow State Technical University, 2-nd Baumanskaya, 5, 105005 Moscow, Russia.

出版信息

Molecules. 2023 Jun 8;28(12):4646. doi: 10.3390/molecules28124646.

DOI:10.3390/molecules28124646
PMID:37375200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10304147/
Abstract

Ultraviolet blood irradiation (UVBI) is an alternative approach to the treatment of infectious diseases of various pathogeneses. Recently, UVBI has attracted particular interest as a new immunomodulatory method. Experimental studies available in the literature demonstrate the absence of precise mechanisms of the effect of ultraviolet radiation (UV) on blood. Here, we investigated the effect of UV radiation of line-spectrum mercury lamp (doses up to 500 mJ/cm) traditionally used in UVBI on the major humoral blood components: albumin, globulins and uric acid. Preliminary data on the effect of various doses of UV radiation of full-spectrum flash xenon lamp (doses up to 136 mJ/cm), a new promising source for UVBI, on the major blood plasma protein, albumin, are presented. The research methodology included spectrofluorimetric analysis of the oxidative modification of proteins and analysis of the antioxidant activity of humoral blood components by chemiluminometry. The effect of UV radiation on albumin caused its oxidative modification and, accordingly, an impairment of the transport properties of the protein. At the same time, UV-modified albumin and γ-globulins acquired pronounced antioxidant properties compared to native samples. Uric acid mixed with albumin did not protect the protein against UV-induced oxidation. The flash full-spectrum UV qualitatively had the same effect on albumin as line-spectrum UV did, but an order of magnitude lower doses were required to achieve comparable effects. The suggested protocol can be used for selecting a safe individual dose for UV therapy.

摘要

紫外线血液辐照（UVBI）是治疗各种病原体感染性疾病的一种替代方法。最近，UVBI 作为一种新的免疫调节方法引起了特别的关注。文献中的实验研究表明，紫外线（UV）对血液的作用机制并不明确。在这里，我们研究了传统用于 UVBI 的线光谱汞灯（剂量高达 500 mJ/cm）的紫外线辐射对主要体液血液成分（白蛋白、球蛋白和尿酸）的影响。同时，还介绍了一种新的有前途的 UVBI 光源——全光谱闪光灯氙灯的各种剂量（剂量高达 136 mJ/cm）对主要血浆蛋白白蛋白的影响的初步数据。该研究方法包括蛋白质氧化修饰的光谱荧光分析和通过化学发光法分析体液血液成分的抗氧化活性。紫外线辐射对白蛋白的作用导致其氧化修饰，从而损害了蛋白质的转运特性。同时，与天然样本相比，经 UV 修饰的白蛋白和γ-球蛋白获得了明显的抗氧化特性。与白蛋白混合的尿酸不能保护蛋白质免受 UV 诱导的氧化。全谱闪光紫外线对白蛋白的作用与线谱紫外线相同，但需要低一个数量级的剂量才能达到可比的效果。所建议的方案可用于选择用于 UV 治疗的安全个体剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/625e5822d66f/molecules-28-04646-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/83da9b5d6c98/molecules-28-04646-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/625e5822d66f/molecules-28-04646-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/0486119a0445/molecules-28-04646-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/e5c7b297d2cc/molecules-28-04646-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/4a7818cd289e/molecules-28-04646-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/877caf1665ef/molecules-28-04646-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/83da9b5d6c98/molecules-28-04646-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/8673d221a795/molecules-28-04646-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5296/10304147/625e5822d66f/molecules-28-04646-g014.jpg

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